Abstract
Parathyroid hormone analog PTH(1–34), used clinically to treat osteoporosis, forms a stable complex with its receptor and prolongs cAMP production even after internalization and recruitment to endosomes. New data suggest this signaling cascade is stimulated by β-arrestins and terminated by retromer
Translated title of the contribution | Signaling: retromer arrests receptor on the run |
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Original language | English |
Pages (from-to) | 251 - 252 |
Number of pages | 2 |
Journal | Nature Chemical Biology |
Volume | 7 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2011 |