Signaling: retromer arrests receptor on the run

JRT van Weering, PJ Cullen

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Abstract

Parathyroid hormone analog PTH(1–34), used clinically to treat osteoporosis, forms a stable complex with its receptor and prolongs cAMP production even after internalization and recruitment to endosomes. New data suggest this signaling cascade is stimulated by β-arrestins and terminated by retromer
Translated title of the contributionSignaling: retromer arrests receptor on the run
Original languageEnglish
Pages (from-to)251 - 252
Number of pages2
JournalNature Chemical Biology
Volume7
Issue number5
DOIs
Publication statusPublished - May 2011

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