Significant intraventricular hemorrhage is more likely in very preterm infants born by vaginal delivery: a multi-centre retrospective cohort study

Islam Gamaleldin*, David Harding, Dimitrios Siassakos, Tim Draycott, David Odd

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)
180 Downloads (Pure)

Abstract

OBJECTIVES: The objective of this study is to determine the association between mode of delivery (vaginal delivery [VD] versus cesarean section [CS]) and the rate of significant intraventricular hemorrhage (sIVH) in preterm infants.

METHODS: A multicenter retrospective cohort study, based on data collected from the Vermont Oxford Network database. Infants born between 23 and 31 +6 weeks of gestational age between 2001 and 2014 were identified. Exposure was the mode of birth (VD versus CS). Primary outcome was development of sIVH. Data were analyzed using univariate and multivariate statistical methods.

RESULTS: A total of 1575 infants were eligible. Nine hundred and two infants were born by CS and 673 by VD. Univariable analysis showed that infants born vaginally were more likely to have sIVH (p < .001), die before discharge (p < .001), have a composite poor outcome (death, sIVH or PVL), need oxygen therapy at 36-week corrected gestation (p = .010) and have a longer hospital stay (p = .006). After adjusting for available confounders, multivariable analysis persistently showed that infants between 23 and 27 weeks born by CS were less likely to develop sIVH [OR 1.61 (1.01-2.58), p = .049].

CONCLUSIONS: sIVH is less common in very preterm infants (23-27 weeks of gestation) delivered by CS. However, neurodevelopmental risks associated with survival at this early age, as well as increased maternal morbidities must also be considered.

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume32
Issue number3
Early online date10 Oct 2017
DOIs
Publication statusPublished - Feb 2019

Keywords

  • Cerebral Hemorrhage/congenital
  • Delivery, Obstetric/adverse effects
  • Female
  • Humans
  • Infant
  • Infant Mortality
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases/epidemiology
  • Infant, Very Low Birth Weight
  • Male
  • Pregnancy
  • Retrospective Studies
  • Severity of Illness Index
  • Vagina

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