Abstract
ABSTRACT PURPOSE: To highlight similarities between the cross-sectional retinal lesion appearance in a patient with punctate inner choroidopathy (PIC), Ebola virus disease (EVD) retinopathy and the von Szily mouse model of herpes simplex virus type 1 (HSV) retinopathy.
METHODS: Case report and cross-sectional retinal lesion comparison.
RESULTS: Whilst phenotypically different on colour imaging, a near-identical lesion appearance on optical coherence tomography, characterised by a focal photoreceptor loss and distinctive V-shaped collapse of the overlying retinal layers, was observed in both PIC and EVD retinopathy. This mirrored the early histological appearance of the neuronally transmitted HSV retinopathy in a mouse model.
CONCLUSIONS: Given the occurrence of this phenotypic appearance has been demonstrated in an animal model where the viral pathophysiological mechanism is known, together with its observation in EVD retinopathy with a shared, hypothesised neurotropic retinal pathogenesis, the potential of a common pathophysiology accounting for the appearance in PIC lesions is a possibility which may provide a potential avenue for future research.
| Original language | English |
|---|---|
| Journal | European Journal of Ophthalmology |
| Early online date | 12 Dec 2022 |
| DOIs | |
| Publication status | E-pub ahead of print - 12 Dec 2022 |
Bibliographical note
Publisher Copyright:© The Author(s) 2022.
Access to Document
- Full-text PDF (accepted author manuscript)
This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Sage at https://doi.org/10.1177/11206721221144. Please refer to any applicable terms of use of the publisher.
- Supplementary material
This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Sage at https://doi.org/10.1177/11206721221144. Please refer to any applicable terms of use of the publisher.
