Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study

Keith Hawton, Helen Bergen, Sue Simkin, Claudia Wells, Navneet Kapur, David Gunnell

Research output: Contribution to journalArticle (Academic Journal)peer-review

52 Citations (Scopus)

Abstract

The analgesic co-proxamol (paracetamol/dextropropoxyphene combination) has been widely involved in fatal poisoning. Concerns about its safety/effectiveness profile and widespread use for suicidal poisoning prompted its withdrawal in the UK in 2005, with partial withdrawal between 2005 and 2007, and full withdrawal in 2008. Our objective in this study was to assess the association between co-proxamol withdrawal and prescribing and deaths in England and Wales in 2005-2010 compared with 1998-2004, including estimation of possible substitution effects by other analgesics.
Original languageEnglish
Pages (from-to)e1001213
JournalPLoS Medicine
Volume9
Issue number5
DOIs
Publication statusPublished - 2012

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