Size matters: just how big is BIG? Quantifying realistic sample size requirements for human genome epidemiology

Paul R Burton, Anna L Hansell, Isabel Fortier, Teri A Manolio, Muin J Khoury, Julian Little, Paul Elliott

Research output: Contribution to journalArticle (Academic Journal)peer-review

187 Citations (Scopus)

Abstract

Despite earlier doubts, a string of recent successes indicates that if sample sizes are large enough, it is possible-both in theory and in practice-to identify and replicate genetic associations with common complex diseases. But human genome epidemiology is expensive and, from a strategic perspective, it is still unclear what 'large enough' really means. This question has critical implications for governments, funding agencies, bioscientists and the tax-paying public. Difficult strategic decisions with imposing price tags and important opportunity costs must be taken.
Original languageEnglish
Pages (from-to)263-273
Number of pages11
JournalInternational Journal of Epidemiology
Volume38
Issue number1
Early online date1 Aug 2008
DOIs
Publication statusPublished - Feb 2009

Keywords

  • Adult
  • Aged
  • Biological Specimen Banks
  • Case-Control Studies
  • Chronic Disease
  • Disease
  • Female
  • Genetic Predisposition to Disease
  • Genomics
  • Humans
  • Life Style
  • Male
  • Middle Aged
  • Research Design
  • Sample Size

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