Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

Karen Horsburgh; Joanna M Wardlaw; Tom van Agtmael; Stuart M Allan; Mike L J Ashford; Philip M Bath; Rosalind Brown; Jason Berwick; M Zameel Cader; Roxana O Carare; Jessica Duncombe; Tracy D Farr; Jill H Fowler; Jozien Goense; Alessandra Granata; Catherine N Hall; Atticus H Hainsworth; Adam Harvey; Cheryl A Hawkes; Anne Joutel; Rajesh N Kalaria; Patrick G Kehoe; Catherine B Lawrence; Andy Lockhart; Seth Love; Malcolm R Macleod; I Mhairi Macrae; Hugh S Markus; Chris McCabe; Barry W McColl; Paul J Meakin; Alyson Miller; Maiken Nedergaard; Terry J Quinn; Rikesh Rajani; Lisa M Saksida; Rhian M Touyz; Rebecca C Trueman; Tao Wang; Lorraine M Work

doi:10.1042/CS20171620

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

Karen Horsburgh, Joanna M Wardlaw, Tom van Agtmael, Stuart M Allan, Mike L J Ashford, Philip M Bath, Rosalind Brown, Jason Berwick, M Zameel Cader, Roxana O Carare, Jessica Duncombe, Tracy D Farr, Jill H Fowler, Jozien Goense, Alessandra Granata, Catherine N Hall, Atticus H Hainsworth, Adam Harvey, Cheryl A Hawkes, Anne JoutelRajesh N Kalaria, Patrick G Kehoe, Catherine B Lawrence, Andy Lockhart, Seth Love, Malcolm R Macleod, I Mhairi Macrae, Hugh S Markus, Chris McCabe, Barry W McColl, Paul J Meakin, Alyson Miller, Maiken Nedergaard, Terry J Quinn, Rikesh Rajani, Lisa M Saksida, Rhian M Touyz, Rebecca C Trueman, Tao Wang, Lorraine M Work

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Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

Original language	English
Pages (from-to)	851-868
Number of pages	18
Journal	Clinical Science
Volume	132
Issue number	8
DOIs	https://doi.org/10.1042/CS20171620
Publication status	Published - 30 Apr 2018

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Journal Article
Review

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10.1042/CS20171620

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Portland Press at http://www.clinsci.org/content/132/8/851.article-info. Please refer to any applicable terms of use of the publisher.
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Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A., ... Work, L. M. (2018). Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132(8), 851-868. https://doi.org/10.1042/CS20171620

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title = "Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology",

abstract = "Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.",

keywords = "Journal Article, Review",

author = "Karen Horsburgh and Wardlaw, {Joanna M} and {van Agtmael}, Tom and Allan, {Stuart M} and Ashford, {Mike L J} and Bath, {Philip M} and Rosalind Brown and Jason Berwick and Cader, {M Zameel} and Carare, {Roxana O} and Jessica Duncombe and Farr, {Tracy D} and Fowler, {Jill H} and Jozien Goense and Alessandra Granata and Hall, {Catherine N} and Hainsworth, {Atticus H} and Adam Harvey and Hawkes, {Cheryl A} and Anne Joutel and Kalaria, {Rajesh N} and Kehoe, {Patrick G} and Lawrence, {Catherine B} and Andy Lockhart and Seth Love and Macleod, {Malcolm R} and Macrae, {I Mhairi} and Markus, {Hugh S} and Chris McCabe and McColl, {Barry W} and Meakin, {Paul J} and Alyson Miller and Maiken Nedergaard and Quinn, {Terry J} and Rikesh Rajani and Saksida, {Lisa M} and Touyz, {Rhian M} and Trueman, {Rebecca C} and Tao Wang and Work, {Lorraine M}",

note = "{\textcopyright} 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.",

year = "2018",

month = apr,

day = "30",

doi = "10.1042/CS20171620",

language = "English",

volume = "132",

pages = "851--868",

journal = "Clinical Science",

issn = "0143-5221",

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Horsburgh, K, Wardlaw, JM, van Agtmael, T, Allan, SM, Ashford, MLJ, Bath, PM, Brown, R, Berwick, J, Cader, MZ, Carare, RO, Duncombe, J, Farr, TD, Fowler, JH, Goense, J, Granata, A, Hall, CN, Hainsworth, AH, Harvey, A, Hawkes, CA, Joutel, A, Kalaria, RN, Kehoe, PG, Lawrence, CB, Lockhart, A, Love, S, Macleod, MR, Macrae, IM, Markus, HS, McCabe, C, McColl, BW, Meakin, PJ, Miller, A, Nedergaard, M, Quinn, TJ, Rajani, R, Saksida, LM, Touyz, RM, Trueman, RC, Wang, T & Work, LM 2018, 'Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology', Clinical Science, vol. 132, no. 8, pp. 851-868. https://doi.org/10.1042/CS20171620

TY - JOUR

T1 - Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

AU - Horsburgh, Karen

AU - Wardlaw, Joanna M

AU - van Agtmael, Tom

AU - Allan, Stuart M

AU - Ashford, Mike L J

AU - Bath, Philip M

AU - Brown, Rosalind

AU - Berwick, Jason

AU - Cader, M Zameel

AU - Carare, Roxana O

AU - Duncombe, Jessica

AU - Farr, Tracy D

AU - Fowler, Jill H

AU - Goense, Jozien

AU - Granata, Alessandra

AU - Hall, Catherine N

AU - Hainsworth, Atticus H

AU - Harvey, Adam

AU - Hawkes, Cheryl A

AU - Joutel, Anne

AU - Kalaria, Rajesh N

AU - Kehoe, Patrick G

AU - Lawrence, Catherine B

AU - Lockhart, Andy

AU - Love, Seth

AU - Macleod, Malcolm R

AU - Macrae, I Mhairi

AU - Markus, Hugh S

AU - McCabe, Chris

AU - McColl, Barry W

AU - Meakin, Paul J

AU - Miller, Alyson

AU - Nedergaard, Maiken

AU - Quinn, Terry J

AU - Rajani, Rikesh

AU - Saksida, Lisa M

AU - Touyz, Rhian M

AU - Trueman, Rebecca C

AU - Wang, Tao

AU - Work, Lorraine M

PY - 2018/4/30

Y1 - 2018/4/30

N2 - Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

AB - Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

KW - Journal Article

KW - Review

U2 - 10.1042/CS20171620

DO - 10.1042/CS20171620

M3 - Review article (Academic Journal)

C2 - 29712883

VL - 132

SP - 851

EP - 868

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 8

ER -

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

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