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Smoking and Preterm Birth

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Smoking and Preterm Birth. / Ion, Rachel; Bernal, Andrés López.

In: Reproductive sciences (Thousand Oaks, Calif.), 12.11.2014.

Research output: Contribution to journalArticle

Harvard

Ion, R & Bernal, AL 2014, 'Smoking and Preterm Birth', Reproductive sciences (Thousand Oaks, Calif.). https://doi.org/10.1177/1933719114556486

APA

Ion, R., & Bernal, A. L. (2014). Smoking and Preterm Birth. Reproductive sciences (Thousand Oaks, Calif.). https://doi.org/10.1177/1933719114556486

Vancouver

Ion R, Bernal AL. Smoking and Preterm Birth. Reproductive sciences (Thousand Oaks, Calif.). 2014 Nov 12. https://doi.org/10.1177/1933719114556486

Author

Ion, Rachel ; Bernal, Andrés López. / Smoking and Preterm Birth. In: Reproductive sciences (Thousand Oaks, Calif.). 2014.

Bibtex

@article{34b00862735e47c782da9293bed625f2,
title = "Smoking and Preterm Birth",
abstract = "Premature birth is a significant global problem and the leading cause of newborn deaths. Tobacco smoking has been associated with premature birth for over 50 years. The mechanisms through which smoking exerts its effects on pregnancy outcomes remain unclear. In this review, we discuss rates of prematurity and smoking in pregnancy, the evidence of a causal relationship between tobacco and preterm birth, and proposed biochemical pathways through which the interaction is mediated. The suggested mechanisms include nicotine-induced vasoconstriction, carbon monoxide-induced fetal hypoxia, cadmium disruption of calcium signaling, altered steroid hormone production, disruption of prostaglandin synthesis, and changed responses to oxytocin. The relative importance of each of these pathways is yet to be ascertained. Further research is necessary to explore the mechanisms through which smoking exerts its effect on gestational length and the process of parturition. Moreover, the risks of nicotine replacement in pregnancy should be investigated further.",
author = "Rachel Ion and Bernal, {Andr{\'e}s L{\'o}pez}",
note = "{\circledC} The Author(s) 2014.",
year = "2014",
month = "11",
day = "12",
doi = "10.1177/1933719114556486",
language = "English",
journal = "Reproductive sciences (Thousand Oaks, Calif.)",
issn = "1933-7205",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Smoking and Preterm Birth

AU - Ion, Rachel

AU - Bernal, Andrés López

N1 - © The Author(s) 2014.

PY - 2014/11/12

Y1 - 2014/11/12

N2 - Premature birth is a significant global problem and the leading cause of newborn deaths. Tobacco smoking has been associated with premature birth for over 50 years. The mechanisms through which smoking exerts its effects on pregnancy outcomes remain unclear. In this review, we discuss rates of prematurity and smoking in pregnancy, the evidence of a causal relationship between tobacco and preterm birth, and proposed biochemical pathways through which the interaction is mediated. The suggested mechanisms include nicotine-induced vasoconstriction, carbon monoxide-induced fetal hypoxia, cadmium disruption of calcium signaling, altered steroid hormone production, disruption of prostaglandin synthesis, and changed responses to oxytocin. The relative importance of each of these pathways is yet to be ascertained. Further research is necessary to explore the mechanisms through which smoking exerts its effect on gestational length and the process of parturition. Moreover, the risks of nicotine replacement in pregnancy should be investigated further.

AB - Premature birth is a significant global problem and the leading cause of newborn deaths. Tobacco smoking has been associated with premature birth for over 50 years. The mechanisms through which smoking exerts its effects on pregnancy outcomes remain unclear. In this review, we discuss rates of prematurity and smoking in pregnancy, the evidence of a causal relationship between tobacco and preterm birth, and proposed biochemical pathways through which the interaction is mediated. The suggested mechanisms include nicotine-induced vasoconstriction, carbon monoxide-induced fetal hypoxia, cadmium disruption of calcium signaling, altered steroid hormone production, disruption of prostaglandin synthesis, and changed responses to oxytocin. The relative importance of each of these pathways is yet to be ascertained. Further research is necessary to explore the mechanisms through which smoking exerts its effect on gestational length and the process of parturition. Moreover, the risks of nicotine replacement in pregnancy should be investigated further.

U2 - 10.1177/1933719114556486

DO - 10.1177/1933719114556486

M3 - Article

JO - Reproductive sciences (Thousand Oaks, Calif.)

JF - Reproductive sciences (Thousand Oaks, Calif.)

SN - 1933-7205

ER -