Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort

Valéria Troncoso Baltar; Wei W Xun; Shu-Chun Chuang; Caroline Relton; Per Magne Ueland; Stein Emil Vollset; Øivind Midttun; Mattias Johansson; Nadia Slimani; Mazda Jenab; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Guy Fagherazzi; Rudolf Kaaks; Sabine Rohrmann; Heiner Boeing; Cornelia Weikert; H Bas Bueno-de-Mesquita; Hendriek C Boshuizen; Carla H van Gils; Petra H M Peeters; Antonio Agudo; Aurelio Barricarte; Carmen Navarro; Laudina Rodríguez; José Maria Huerta Castaño; Nerea Larrañaga; Maria José Sánchez Pérez; Kay-Tee Khaw; Nick Wareham; Naomi E Allen; Francesca Crowe; Valentina Gallo; Teresa Norat; Giovanna Tagliabue; Giovanna Masala; Salvatore Panico; Carlota Sacerdote; Rosario Tumino; Antonia Trichopoulou; Pagona Lagiou; Christina Bamia; Torgny Rasmuson; Göran Hallmans; Nina Roswall; Anne Tjønneland; Elio Riboli; Paul Brennan; Paolo Vineis

doi:10.1158/1055-9965.EPI-10-1235

Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort

Valéria Troncoso Baltar, Wei W Xun, Shu-Chun Chuang, Caroline Relton, Per Magne Ueland, Stein Emil Vollset, Øivind Midttun, Mattias Johansson, Nadia Slimani, Mazda Jenab, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Rudolf Kaaks, Sabine Rohrmann, Heiner Boeing, Cornelia Weikert, H Bas Bueno-de-Mesquita, Hendriek C Boshuizen, Carla H van GilsPetra H M Peeters, Antonio Agudo, Aurelio Barricarte, Carmen Navarro, Laudina Rodríguez, José Maria Huerta Castaño, Nerea Larrañaga, Maria José Sánchez Pérez, Kay-Tee Khaw, Nick Wareham, Naomi E Allen, Francesca Crowe, Valentina Gallo, Teresa Norat, Giovanna Tagliabue, Giovanna Masala, Salvatore Panico, Carlota Sacerdote, Rosario Tumino, Antonia Trichopoulou, Pagona Lagiou, Christina Bamia, Torgny Rasmuson, Göran Hallmans, Nina Roswall, Anne Tjønneland, Elio Riboli, Paul Brennan, Paolo Vineis

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

BACKGROUND: Several countries are discussing new legislation regarding the ban on smoking in public places, based on the growing evidence of the hazards of secondhand smoke (SHS) exposure. The objective of the present study is to quantitatively assess the relationship between smoking, SHS, and serum cotinine levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

METHODS: From a study on lung cancer in the EPIC cohort, questionnaire information on smoking was collected at enrolment, and cotinine was measured in serum. Three statistical models were applied by using samples available in a cross-section design: (i) cotinine levels by categories combining smoking and SHS (n = 859); (ii) the effect of hours of passive smoking exposure in nonsmokers only (n = 107); (iii) the effect of the number of cigarettes consumed per day in current smokers only (n = 832). All models were adjusted for country, sex, age, and body mass index.

RESULTS: Among nonsmokers, passive smokers presented significant differences in cotinine compared with nonexposed, with a marked (but not significant) difference among former-smokers. A one hour per day increment of SHS gave rise to a significant 2.58 nmol/L (0.45 ng/mL) increase in mean serum cotinine (P < 0.001). In current smokers, a one cigarette per day increment gave rise to a significant 22.44 nmol/L (3.95 ng/mL) increase in cotinine mean (P < 0.001).

CONCLUSIONS: There is clear evidence that not only tobacco smoking but also involuntary exposure increases cotinine levels.

IMPACT: This study strengthens the evidence for the benefits of a smoking ban in public places.

Original language	English
Pages (from-to)	869-75
Number of pages	7
Journal	Cancer Epidemiology, Biomarkers and Prevention
Volume	20
Issue number	5
DOIs	https://doi.org/10.1158/1055-9965.EPI-10-1235
Publication status	Published - May 2011

Bibliographical note

Keywords

Adult
Aged
Case-Control Studies
Cohort Studies
Cotinine
Cross-Sectional Studies
Europe
European Continental Ancestry Group
Female
Humans
Lung Neoplasms
Male
Middle Aged
Prognosis
Prospective Studies
Smoking
Tobacco Smoke Pollution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Baltar, V. T., Xun, W. W., Chuang, S.-C., Relton, C., Ueland, P. M., Vollset, S. E., Midttun, Ø., Johansson, M., Slimani, N., Jenab, M., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Fagherazzi, G., Kaaks, R., Rohrmann, S., Boeing, H., Weikert, C., Bueno-de-Mesquita, H. B., Boshuizen, H. C., ... Vineis, P. (2011). Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort. Cancer Epidemiology, Biomarkers and Prevention, 20(5), 869-75. https://doi.org/10.1158/1055-9965.EPI-10-1235

@article{e341fa7eab294fc296e44ef32a8f7524,

title = "Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort",

abstract = "BACKGROUND: Several countries are discussing new legislation regarding the ban on smoking in public places, based on the growing evidence of the hazards of secondhand smoke (SHS) exposure. The objective of the present study is to quantitatively assess the relationship between smoking, SHS, and serum cotinine levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: From a study on lung cancer in the EPIC cohort, questionnaire information on smoking was collected at enrolment, and cotinine was measured in serum. Three statistical models were applied by using samples available in a cross-section design: (i) cotinine levels by categories combining smoking and SHS (n = 859); (ii) the effect of hours of passive smoking exposure in nonsmokers only (n = 107); (iii) the effect of the number of cigarettes consumed per day in current smokers only (n = 832). All models were adjusted for country, sex, age, and body mass index.RESULTS: Among nonsmokers, passive smokers presented significant differences in cotinine compared with nonexposed, with a marked (but not significant) difference among former-smokers. A one hour per day increment of SHS gave rise to a significant 2.58 nmol/L (0.45 ng/mL) increase in mean serum cotinine (P < 0.001). In current smokers, a one cigarette per day increment gave rise to a significant 22.44 nmol/L (3.95 ng/mL) increase in cotinine mean (P < 0.001).CONCLUSIONS: There is clear evidence that not only tobacco smoking but also involuntary exposure increases cotinine levels.IMPACT: This study strengthens the evidence for the benefits of a smoking ban in public places.",

keywords = "Adult, Aged, Case-Control Studies, Cohort Studies, Cotinine, Cross-Sectional Studies, Europe, European Continental Ancestry Group, Female, Humans, Lung Neoplasms, Male, Middle Aged, Prognosis, Prospective Studies, Smoking, Tobacco Smoke Pollution",

author = "Baltar, {Val{\'e}ria Troncoso} and Xun, {Wei W} and Shu-Chun Chuang and Caroline Relton and Ueland, {Per Magne} and Vollset, {Stein Emil} and {\O}ivind Midttun and Mattias Johansson and Nadia Slimani and Mazda Jenab and Fran{\c c}oise Clavel-Chapelon and Marie-Christine Boutron-Ruault and Guy Fagherazzi and Rudolf Kaaks and Sabine Rohrmann and Heiner Boeing and Cornelia Weikert and Bueno-de-Mesquita, {H Bas} and Boshuizen, {Hendriek C} and {van Gils}, {Carla H} and Peeters, {Petra H M} and Antonio Agudo and Aurelio Barricarte and Carmen Navarro and Laudina Rodr{\'i}guez and Casta{\~n}o, {Jos{\'e} Maria Huerta} and Nerea Larra{\~n}aga and P{\'e}rez, {Maria Jos{\'e} S{\'a}nchez} and Kay-Tee Khaw and Nick Wareham and Allen, {Naomi E} and Francesca Crowe and Valentina Gallo and Teresa Norat and Giovanna Tagliabue and Giovanna Masala and Salvatore Panico and Carlota Sacerdote and Rosario Tumino and Antonia Trichopoulou and Pagona Lagiou and Christina Bamia and Torgny Rasmuson and G{\"o}ran Hallmans and Nina Roswall and Anne Tj{\o}nneland and Elio Riboli and Paul Brennan and Paolo Vineis",

note = "{\textcopyright}2011 AACR.",

year = "2011",

month = may,

doi = "10.1158/1055-9965.EPI-10-1235",

language = "English",

volume = "20",

pages = "869--75",

journal = "Cancer Epidemiology, Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "5",

}

Baltar, VT, Xun, WW, Chuang, S-C, Relton, C, Ueland, PM, Vollset, SE, Midttun, Ø, Johansson, M, Slimani, N, Jenab, M, Clavel-Chapelon, F, Boutron-Ruault, M-C, Fagherazzi, G, Kaaks, R, Rohrmann, S, Boeing, H, Weikert, C, Bueno-de-Mesquita, HB, Boshuizen, HC, van Gils, CH, Peeters, PHM, Agudo, A, Barricarte, A, Navarro, C, Rodríguez, L, Castaño, JMH, Larrañaga, N, Pérez, MJS, Khaw, K-T, Wareham, N, Allen, NE, Crowe, F, Gallo, V, Norat, T, Tagliabue, G, Masala, G, Panico, S, Sacerdote, C, Tumino, R, Trichopoulou, A, Lagiou, P, Bamia, C, Rasmuson, T, Hallmans, G, Roswall, N, Tjønneland, A, Riboli, E, Brennan, P & Vineis, P 2011, 'Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort', Cancer Epidemiology, Biomarkers and Prevention, vol. 20, no. 5, pp. 869-75. https://doi.org/10.1158/1055-9965.EPI-10-1235

TY - JOUR

T1 - Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort

AU - Baltar, Valéria Troncoso

AU - Xun, Wei W

AU - Chuang, Shu-Chun

AU - Relton, Caroline

AU - Ueland, Per Magne

AU - Vollset, Stein Emil

AU - Midttun, Øivind

AU - Johansson, Mattias

AU - Slimani, Nadia

AU - Jenab, Mazda

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie-Christine

AU - Fagherazzi, Guy

AU - Kaaks, Rudolf

AU - Rohrmann, Sabine

AU - Boeing, Heiner

AU - Weikert, Cornelia

AU - Bueno-de-Mesquita, H Bas

AU - Boshuizen, Hendriek C

AU - van Gils, Carla H

AU - Peeters, Petra H M

AU - Agudo, Antonio

AU - Barricarte, Aurelio

AU - Navarro, Carmen

AU - Rodríguez, Laudina

AU - Castaño, José Maria Huerta

AU - Larrañaga, Nerea

AU - Pérez, Maria José Sánchez

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Allen, Naomi E

AU - Crowe, Francesca

AU - Gallo, Valentina

AU - Norat, Teresa

AU - Tagliabue, Giovanna

AU - Masala, Giovanna

AU - Panico, Salvatore

AU - Sacerdote, Carlota

AU - Tumino, Rosario

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Bamia, Christina

AU - Rasmuson, Torgny

AU - Hallmans, Göran

AU - Roswall, Nina

AU - Tjønneland, Anne

AU - Riboli, Elio

AU - Brennan, Paul

AU - Vineis, Paolo

PY - 2011/5

Y1 - 2011/5

N2 - BACKGROUND: Several countries are discussing new legislation regarding the ban on smoking in public places, based on the growing evidence of the hazards of secondhand smoke (SHS) exposure. The objective of the present study is to quantitatively assess the relationship between smoking, SHS, and serum cotinine levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: From a study on lung cancer in the EPIC cohort, questionnaire information on smoking was collected at enrolment, and cotinine was measured in serum. Three statistical models were applied by using samples available in a cross-section design: (i) cotinine levels by categories combining smoking and SHS (n = 859); (ii) the effect of hours of passive smoking exposure in nonsmokers only (n = 107); (iii) the effect of the number of cigarettes consumed per day in current smokers only (n = 832). All models were adjusted for country, sex, age, and body mass index.RESULTS: Among nonsmokers, passive smokers presented significant differences in cotinine compared with nonexposed, with a marked (but not significant) difference among former-smokers. A one hour per day increment of SHS gave rise to a significant 2.58 nmol/L (0.45 ng/mL) increase in mean serum cotinine (P < 0.001). In current smokers, a one cigarette per day increment gave rise to a significant 22.44 nmol/L (3.95 ng/mL) increase in cotinine mean (P < 0.001).CONCLUSIONS: There is clear evidence that not only tobacco smoking but also involuntary exposure increases cotinine levels.IMPACT: This study strengthens the evidence for the benefits of a smoking ban in public places.

AB - BACKGROUND: Several countries are discussing new legislation regarding the ban on smoking in public places, based on the growing evidence of the hazards of secondhand smoke (SHS) exposure. The objective of the present study is to quantitatively assess the relationship between smoking, SHS, and serum cotinine levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: From a study on lung cancer in the EPIC cohort, questionnaire information on smoking was collected at enrolment, and cotinine was measured in serum. Three statistical models were applied by using samples available in a cross-section design: (i) cotinine levels by categories combining smoking and SHS (n = 859); (ii) the effect of hours of passive smoking exposure in nonsmokers only (n = 107); (iii) the effect of the number of cigarettes consumed per day in current smokers only (n = 832). All models were adjusted for country, sex, age, and body mass index.RESULTS: Among nonsmokers, passive smokers presented significant differences in cotinine compared with nonexposed, with a marked (but not significant) difference among former-smokers. A one hour per day increment of SHS gave rise to a significant 2.58 nmol/L (0.45 ng/mL) increase in mean serum cotinine (P < 0.001). In current smokers, a one cigarette per day increment gave rise to a significant 22.44 nmol/L (3.95 ng/mL) increase in cotinine mean (P < 0.001).CONCLUSIONS: There is clear evidence that not only tobacco smoking but also involuntary exposure increases cotinine levels.IMPACT: This study strengthens the evidence for the benefits of a smoking ban in public places.

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Cohort Studies

KW - Cotinine

KW - Cross-Sectional Studies

KW - Europe

KW - European Continental Ancestry Group

KW - Female

KW - Humans

KW - Lung Neoplasms

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Prospective Studies

KW - Smoking

KW - Tobacco Smoke Pollution

U2 - 10.1158/1055-9965.EPI-10-1235

DO - 10.1158/1055-9965.EPI-10-1235

M3 - Article (Academic Journal)

C2 - 21357382

SN - 1055-9965

VL - 20

SP - 869

EP - 875

JO - Cancer Epidemiology, Biomarkers and Prevention

JF - Cancer Epidemiology, Biomarkers and Prevention

IS - 5

ER -

Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort

Abstract

Bibliographical note

Keywords

UN SDGs

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