Sociodemographic features and mortality of individuals on haemodialysis treatment who test positive for SARS-CoV-2: A UK Renal Registry data analysis

Manuela Savino; Anna Casula; Shalini  Santhakumaran; David Pitcher; Esther Wong; Winnie Magadi; Katharine Evans; Fran Benoy-Deeney; James Griffin; Lucy Plumb; Retha Steenkamp; Dorothea Nitsch; James Medcalf

Sociodemographic features and mortality of individuals on haemodialysis treatment who test positive for SARS-CoV-2: A UK Renal Registry data analysis

Manuela Savino^*, Anna Casula, Shalini Santhakumaran, David Pitcher, Esther Wong, Winnie Magadi, Katharine Evans, Fran Benoy-Deeney, James Griffin, Lucy Plumb, Retha Steenkamp, Dorothea Nitsch, James Medcalf

^*Corresponding author for this work

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Abstract

Kidney disease is a recognised risk factor for poor COVID-19 outcomes. Up to 30 June 2020, the UK Renal Registry (UKRR) collected data for 2,385 in-centre haemodialysis (ICHD) patients with COVID-19 in England and Wales. Overall unadjusted survival at 1 week after date of positive COVID-19 test was 87.5% (95% CI 86.1–88.8%); mortality increased with age, treatment vintage and there was borderline evidence of Asian ethnicity (HR 1.16, 95% CI 0.94–1.44) being associated with higher mortality. Compared to the general population, the relative risk of mortality for ICHD patients with COVID-19 was 45.4 and highest in younger adults. This retrospective cohort study based on UKRR data supports efforts to protect this vulnerable patient group.

Original language	English
Article number	E0241263
Number of pages	8
Journal	PLoS ONE
Volume	15
Issue number	10
Publication status	Published - 23 Oct 2020

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Covid19

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Savino, M., Casula, A., Santhakumaran, S., Pitcher, D., Wong, E., Magadi, W., Evans, K., Benoy-Deeney, F., Griffin, J., Plumb, L., Steenkamp, R., Nitsch, D., & Medcalf, J. (2020). Sociodemographic features and mortality of individuals on haemodialysis treatment who test positive for SARS-CoV-2: A UK Renal Registry data analysis. PLoS ONE, 15(10), Article E0241263. http://10.1371/journal.pone.0241263

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abstract = "Kidney disease is a recognised risk factor for poor COVID-19 outcomes. Up to 30 June 2020, the UK Renal Registry (UKRR) collected data for 2,385 in-centre haemodialysis (ICHD) patients with COVID-19 in England and Wales. Overall unadjusted survival at 1 week after date of positive COVID-19 test was 87.5% (95% CI 86.1–88.8%); mortality increased with age, treatment vintage and there was borderline evidence of Asian ethnicity (HR 1.16, 95% CI 0.94–1.44) being associated with higher mortality. Compared to the general population, the relative risk of mortality for ICHD patients with COVID-19 was 45.4 and highest in younger adults. This retrospective cohort study based on UKRR data supports efforts to protect this vulnerable patient group.",

author = "Manuela Savino and Anna Casula and Shalini Santhakumaran and David Pitcher and Esther Wong and Winnie Magadi and Katharine Evans and Fran Benoy-Deeney and James Griffin and Lucy Plumb and Retha Steenkamp and Dorothea Nitsch and James Medcalf",

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Savino, M, Casula, A, Santhakumaran, S, Pitcher, D, Wong, E, Magadi, W, Evans, K, Benoy-Deeney, F, Griffin, J, Plumb, L, Steenkamp, R, Nitsch, D & Medcalf, J 2020, 'Sociodemographic features and mortality of individuals on haemodialysis treatment who test positive for SARS-CoV-2: A UK Renal Registry data analysis', PLoS ONE, vol. 15, no. 10, E0241263. <http://10.1371/journal.pone.0241263>

TY - JOUR

T1 - Sociodemographic features and mortality of individuals on haemodialysis treatment who test positive for SARS-CoV-2

T2 - A UK Renal Registry data analysis

AU - Savino, Manuela

AU - Casula, Anna

AU - Santhakumaran, Shalini

AU - Pitcher, David

AU - Wong, Esther

AU - Magadi, Winnie

AU - Evans, Katharine

AU - Benoy-Deeney, Fran

AU - Griffin, James

AU - Plumb, Lucy

AU - Steenkamp, Retha

AU - Nitsch, Dorothea

AU - Medcalf, James

PY - 2020/10/23

Y1 - 2020/10/23

N2 - Kidney disease is a recognised risk factor for poor COVID-19 outcomes. Up to 30 June 2020, the UK Renal Registry (UKRR) collected data for 2,385 in-centre haemodialysis (ICHD) patients with COVID-19 in England and Wales. Overall unadjusted survival at 1 week after date of positive COVID-19 test was 87.5% (95% CI 86.1–88.8%); mortality increased with age, treatment vintage and there was borderline evidence of Asian ethnicity (HR 1.16, 95% CI 0.94–1.44) being associated with higher mortality. Compared to the general population, the relative risk of mortality for ICHD patients with COVID-19 was 45.4 and highest in younger adults. This retrospective cohort study based on UKRR data supports efforts to protect this vulnerable patient group.

AB - Kidney disease is a recognised risk factor for poor COVID-19 outcomes. Up to 30 June 2020, the UK Renal Registry (UKRR) collected data for 2,385 in-centre haemodialysis (ICHD) patients with COVID-19 in England and Wales. Overall unadjusted survival at 1 week after date of positive COVID-19 test was 87.5% (95% CI 86.1–88.8%); mortality increased with age, treatment vintage and there was borderline evidence of Asian ethnicity (HR 1.16, 95% CI 0.94–1.44) being associated with higher mortality. Compared to the general population, the relative risk of mortality for ICHD patients with COVID-19 was 45.4 and highest in younger adults. This retrospective cohort study based on UKRR data supports efforts to protect this vulnerable patient group.

M3 - Article (Academic Journal)

SN - 1932-6203

VL - 15

JO - PLoS ONE

JF - PLoS ONE

IS - 10

M1 - E0241263

ER -

Sociodemographic features and mortality of individuals on haemodialysis treatment who test positive for SARS-CoV-2: A UK Renal Registry data analysis

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