Spatially controlling neuronal adhesion and inflammatory reactions on implantable diamond

E.M Regan; A Taylor; P.W May; J.B Uney; A.D Dick; J.P McGeehan

doi:10.1109/JETCAS.2011.2174469

Spatially controlling neuronal adhesion and inflammatory reactions on implantable diamond

E.M Regan
, A Taylor
, P.W May
, J.B Uney
, A.D Dick
, J.P McGeehan

Research output: Contribution to journal › Article (Academic Journal) › peer-review

9 Citations (Scopus)

581 Downloads (Pure)

Abstract

The mechanical and chemical properties of diamond and diamond-like carbon (DLC) coatings make them very suitable materials for improving the long-term performance of invasive electrode systems used in brain–computer interfaces (BCIs). We have performed in vitro testing to demonstrate methods for spatially directing neural cell growth and limiting the detrimental attachment of cells involved in the foreign body response on boron-doped diamond and DLC. Inkjet-printing, laser micro-machining, and stencil-assisted patterning techniques were used to control neuronal adhesion and modify inflammatory cell attachment. This work presents micro-tailored materials that could be used to improve the long-term quality of recorded signals from neural-electronic interfaces.

Translated title of the contribution	Spatially controlling neuronal adhesion and inflammatory reactions on implantable diamond
Original language	English
Pages (from-to)	557 - 565
Number of pages	9
Journal	IEEE Journal of Emerging and Selected Topics in Circuits and Systems
Volume	1
Issue number	4
DOIs	https://doi.org/10.1109/JETCAS.2011.2174469
Publication status	Published - Dec 2011

Bibliographical note

Publisher: IEEE
Rose publication type: Article

Sponsorship: This work was supported by Micron Foundation

Terms of use: Copyright © 2011 IEEE. Reprinted with permission, from EM Regan, A Taylor, P May, J Uney, A Dick, JP McGeehan; 'Spatially controlling neuronal adhesion and inflammatory reactions on implantable diamond'; IEEE Journal on Emerging and Selected Topics in Circuits and Systems, December 2011. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of the University of Bristol's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to [email protected].

By choosing to view this document, you agree to all provisions of the copyright laws protecting it.

Research Groups and Themes

Physical & Theoretical

Keywords

neuron
brain-computer interface
diamond
glia

Access to Document

10.1109/JETCAS.2011.2174469

Journal paperAccepted author manuscript, 1.3 MB

http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6095349

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Persistent link

9 Citations
1 Article (Academic Journal)
1 Review article (Academic Journal)

Diamond thin films: giving biomedical applications a new shine
Nistor, P. & May, P., Sept 2017, In: Journal of the Royal Society Interface. 14, 134, 15 p., 20170382.
Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access
File
89 Citations (Scopus)

375 Downloads (Pure)
Photochemically modified diamond-like carbon surfaces for neural interfaces
May, P., Hopper, A. P., Dugan, J. M., Gill, A. A., Haycock, J. W., Claeyssens, F., Regan, E. M. & Kelly, S., 8 Sept 2015, In: Materials Science and Engineering C. 58, p. 1199-1206
Research output: Contribution to journal › Article (Academic Journal) › peer-review
10 Citations (Scopus)

Cite this

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title = "Spatially controlling neuronal adhesion and inflammatory reactions on implantable diamond",

abstract = "The mechanical and chemical properties of diamond and diamond-like carbon (DLC) coatings make them very suitable materials for improving the long-term performance of invasive electrode systems used in brain–computer interfaces (BCIs). We have performed in vitro testing to demonstrate methods for spatially directing neural cell growth and limiting the detrimental attachment of cells involved in the foreign body response on boron-doped diamond and DLC. Inkjet-printing, laser micro-machining, and stencil-assisted patterning techniques were used to control neuronal adhesion and modify inflammatory cell attachment. This work presents micro-tailored materials that could be used to improve the long-term quality of recorded signals from neural-electronic interfaces.",

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note = "Publisher: IEEE Rose publication type: Article Sponsorship: This work was supported by Micron Foundation Terms of use: Copyright {\textcopyright} 2011 IEEE. Reprinted with permission, from EM Regan, A Taylor, P May, J Uney, A Dick, JP McGeehan; 'Spatially controlling neuronal adhesion and inflammatory reactions on implantable diamond'; IEEE Journal on Emerging and Selected Topics in Circuits and Systems, December 2011. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of the University of Bristol's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to [email protected]. By choosing to view this document, you agree to all provisions of the copyright laws protecting it. ",

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Spatially controlling neuronal adhesion and inflammatory reactions on implantable diamond

Abstract

Bibliographical note

Research Groups and Themes

Keywords

Access to Document

Handle.net

Fingerprint

Research output

Diamond thin films: giving biomedical applications a new shine

Photochemically modified diamond-like carbon surfaces for neural interfaces

Cite this