Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner

Haonan Liu; Molly L Jackson; Lucy J Goudswaard; Samantha Frances Moore; J L Hutchinson; Ingeborg Hers

doi:10.1038/s41598-021-94052-4

Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner

Haonan Liu
, Molly L Jackson
, Lucy J Goudswaard
, Samantha Frances Moore
, J L Hutchinson
, Ingeborg Hers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

18 Citations (Scopus)

112 Downloads (Pure)

Original language	English
Article number	15308
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-94052-4
Publication status	Published - 28 Jul 2021

Bibliographical note

Funding Information:
This work was supported by the British Heart Foundation (PG/14/3/305650, PG/16/3/31833) and Bristol Alumni. We thank Elizabeth Aitken and Dr. Tony Walsh for technical support and the blood donors within the Biomedical Sciences building at the University of Bristol.

Publisher Copyright:
© 2021, The Author(s).

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title = "Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner",

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note = "Funding Information: This work was supported by the British Heart Foundation (PG/14/3/305650, PG/16/3/31833) and Bristol Alumni. We thank Elizabeth Aitken and Dr. Tony Walsh for technical support and the blood donors within the Biomedical Sciences building at the University of Bristol. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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AU - Jackson, Molly L

AU - Goudswaard, Lucy J

AU - Moore, Samantha Frances

AU - Hutchinson, J L

AU - Hers, Ingeborg

N1 - Funding Information: This work was supported by the British Heart Foundation (PG/14/3/305650, PG/16/3/31833) and Bristol Alumni. We thank Elizabeth Aitken and Dr. Tony Walsh for technical support and the blood donors within the Biomedical Sciences building at the University of Bristol. Publisher Copyright: © 2021, The Author(s).

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DO - 10.1038/s41598-021-94052-4

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