Spirometric lung function in school-age children: effect of intrauterine growth retardation and catch-up growth

Sarah J Kotecha, W John Watkins, Jonathan Heron, John Henderson, Frank D Dunstan, Sailesh Kotecha

Research output: Contribution to journalArticle (Academic Journal)peer-review

100 Citations (Scopus)

Abstract

RATIONALE: Few studies have investigated childhood respiratory outcomes of intrauterine growth retardation (IUGR), and it is unclear if catch-up growth in these children influences lung function.

OBJECTIVES: We determined if lung function differed in 8- to 9-year-old children born at term with or without growth retardation, and, in the growth-retarded group, if lung function differed between those who did and those who did not show weight catch up.

METHODS: Caucasian singleton births of 37 weeks or longer gestation from the Avon Longitudinal Study of Parents and Children (n = 14,062) who had lung spirometry at 8-9 years of age were included (n = 5,770).

MEASUREMENTS AND MAIN RESULTS: Infants with gestation-appropriate birthweight (n = 3,462) had significantly better lung function at 8-9 years of age than those with IUGR (i.e., birthweight <10th centile [n = 576] [SD differences and confidence intervals adjusted for sex, gestation, maternal smoking during pregnancy, and social class: FEV(1), -0.198 (-0.294 to -0.102), FVC, -0.131 (-0.227 to -0.036), forced midexpiratory flow between 25 and 75% of vital capacity -0.149 (-0.246 to -0.053)]). Both groups had similar respiratory symptoms. All spirometry measurements were higher in children with IUGR who had weight catch-up growth (n = 430) than in those without (n = 146), although the differences were not statistically significant. Both groups remained significantly lower than control subjects. Growth-retarded asymmetric and symmetric children had similar lung function.

CONCLUSIONS: IUGR is associated with poorer lung function at 8-9 years of age compared with control children. Although the differences were not statistically significant, spirometry was higher in children who showed weight catch-up growth, but remained significantly lower than the control children.

Original languageEnglish
Pages (from-to)969-74
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume181
Issue number9
DOIs
Publication statusPublished - 1 May 2010

Keywords

  • Birth Weight
  • Body Weight
  • Child
  • Female
  • Fetal Growth Retardation
  • Growth
  • Humans
  • Infant, Newborn
  • Longitudinal Studies
  • Male
  • Pregnancy
  • Pregnancy Complications
  • Smoking
  • Socioeconomic Factors
  • Spirometry

Fingerprint Dive into the research topics of 'Spirometric lung function in school-age children: effect of intrauterine growth retardation and catch-up growth'. Together they form a unique fingerprint.

Cite this