Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat

Sara Kelly; J P Dunham; F Murray; S Read; L F Donaldson; S N Lawson

doi:10.1016/j.joca.2012.01.002

Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat

Sara Kelly, J P Dunham, F Murray, S Read, L F Donaldson, S N Lawson

Research output: Contribution to journal › Article (Academic Journal) › peer-review

52 Citations (Scopus)

Abstract

Osteoarthritis (OA) pain mechanisms are poorly understood. We used the monosodium iodoacetate (MIA) model of knee OA to characterize changes in excitability during the course of OA in different classes of mechanosensitive afferents projecting to joint-associated tissues, and examine whether these afferent responses and pain behavior are correlated.

Original language	English
Pages (from-to)	305-13
Number of pages	9
Journal	Osteoarthritis and Cartilage
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.joca.2012.01.002
Publication status	Published - 2012

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Kelly, S., Dunham, J. P., Murray, F., Read, S., Donaldson, L. F., & Lawson, S. N. (2012). Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat. Osteoarthritis and Cartilage, 20(4), 305-13. https://doi.org/10.1016/j.joca.2012.01.002

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title = "Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat",

abstract = "Osteoarthritis (OA) pain mechanisms are poorly understood. We used the monosodium iodoacetate (MIA) model of knee OA to characterize changes in excitability during the course of OA in different classes of mechanosensitive afferents projecting to joint-associated tissues, and examine whether these afferent responses and pain behavior are correlated.",

author = "Sara Kelly and Dunham, {J P} and F Murray and S Read and Donaldson, {L F} and Lawson, {S N}",

year = "2012",

doi = "10.1016/j.joca.2012.01.002",

language = "English",

volume = "20",

pages = "305--13",

journal = "Osteoarthritis and Cartilage",

issn = "1522-9653",

publisher = "W.B. Saunders",

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}

Kelly, S, Dunham, JP, Murray, F, Read, S, Donaldson, LF & Lawson, SN 2012, 'Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat', Osteoarthritis and Cartilage, vol. 20, no. 4, pp. 305-13. https://doi.org/10.1016/j.joca.2012.01.002

Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat. / Kelly, Sara; Dunham, J P; Murray, F et al.
In: Osteoarthritis and Cartilage, Vol. 20, No. 4, 2012, p. 305-13.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat

AU - Kelly, Sara

AU - Dunham, J P

AU - Murray, F

AU - Read, S

AU - Donaldson, L F

AU - Lawson, S N

PY - 2012

Y1 - 2012

N2 - Osteoarthritis (OA) pain mechanisms are poorly understood. We used the monosodium iodoacetate (MIA) model of knee OA to characterize changes in excitability during the course of OA in different classes of mechanosensitive afferents projecting to joint-associated tissues, and examine whether these afferent responses and pain behavior are correlated.

AB - Osteoarthritis (OA) pain mechanisms are poorly understood. We used the monosodium iodoacetate (MIA) model of knee OA to characterize changes in excitability during the course of OA in different classes of mechanosensitive afferents projecting to joint-associated tissues, and examine whether these afferent responses and pain behavior are correlated.

U2 - 10.1016/j.joca.2012.01.002

DO - 10.1016/j.joca.2012.01.002

M3 - Article (Academic Journal)

C2 - 22285737

SN - 1522-9653

VL - 20

SP - 305

EP - 313

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 4

ER -

Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat

Abstract

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