Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat

Sara Kelly, J P Dunham, F Murray, S Read, L F Donaldson, S N Lawson

Research output: Contribution to journalArticle (Academic Journal)peer-review

40 Citations (Scopus)

Abstract

Osteoarthritis (OA) pain mechanisms are poorly understood. We used the monosodium iodoacetate (MIA) model of knee OA to characterize changes in excitability during the course of OA in different classes of mechanosensitive afferents projecting to joint-associated tissues, and examine whether these afferent responses and pain behavior are correlated.
Original languageEnglish
Pages (from-to)305-13
Number of pages9
JournalOsteoarthritis and Cartilage
Volume20
Issue number4
DOIs
Publication statusPublished - 2012

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