Spontaneous membrane-less multi-compartmentalisation via aqueous two-phase separation in complex coacervate microdroplets

Nicolette G Moreau; Nicolas C Martin; Pierangelo Gobbo; T D Tang; Stephen Mann

doi:10.1039/d0cc05399f

Spontaneous membrane-less multi-compartmentalisation via aqueous two-phase separation in complex coacervate microdroplets

Nicolette G Moreau, Nicolas C Martin, Pierangelo Gobbo, T D Tang, Stephen Mann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Polyelectrolyte/nucleotide multiphase complex coacervate droplets are produced by internalized aqueous two-phase separation and used for the spatially dependent chemical transfer of sugar molecules, providing a step towards the development of membrane-free “organelles” within coacervate-based protocells.

Original language	English
Pages (from-to)	12717-12720
Number of pages	5
Journal	Chem. Commun.
Volume	56
Early online date	10 Sept 2020
DOIs	https://doi.org/10.1039/d0cc05399f
Publication status	Published - 28 Oct 2020

Research Groups and Themes

BrisSynBio
Bristol BioDesign Institute
Max Planck Bristol

Keywords

synthetic biology

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10.1039/d0cc05399f

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This is the final published version of the article (version of record). It first appeared online via Royal Society of Chemistry at https://doi.org/10.1039/d0cc05399f . Please refer to any applicable terms of use of the publisher.
Final published version, 2.92 MBLicence: CC BY

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title = "Spontaneous membrane-less multi-compartmentalisation via aqueous two-phase separation in complex coacervate microdroplets",

abstract = "Polyelectrolyte/nucleotide multiphase complex coacervate droplets are produced by internalized aqueous two-phase separation and used for the spatially dependent chemical transfer of sugar molecules, providing a step towards the development of membrane-free “organelles” within coacervate-based protocells.",

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author = "Moreau, {Nicolette G} and Martin, {Nicolas C} and Pierangelo Gobbo and Tang, {T D} and Stephen Mann",

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T1 - Spontaneous membrane-less multi-compartmentalisation via aqueous two-phase separation in complex coacervate microdroplets

AU - Moreau, Nicolette G

AU - Martin, Nicolas C

AU - Gobbo, Pierangelo

AU - Tang, T D

AU - Mann, Stephen

PY - 2020/10/28

Y1 - 2020/10/28

N2 - Polyelectrolyte/nucleotide multiphase complex coacervate droplets are produced by internalized aqueous two-phase separation and used for the spatially dependent chemical transfer of sugar molecules, providing a step towards the development of membrane-free “organelles” within coacervate-based protocells.

AB - Polyelectrolyte/nucleotide multiphase complex coacervate droplets are produced by internalized aqueous two-phase separation and used for the spatially dependent chemical transfer of sugar molecules, providing a step towards the development of membrane-free “organelles” within coacervate-based protocells.

KW - synthetic biology

U2 - 10.1039/d0cc05399f

DO - 10.1039/d0cc05399f

M3 - Article (Academic Journal)

C2 - 32945817

VL - 56

SP - 12717

EP - 12720

JO - Chem. Commun.

JF - Chem. Commun.

ER -

Spontaneous membrane-less multi-compartmentalisation via aqueous two-phase separation in complex coacervate microdroplets

Abstract

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