Spontaneous Membranization in a Silk-Based Coacervate Protocell Model

Zhuping Yin; Liangfei Tian; Avinash J Patil; Mei Li; Stephen Mann

doi:10.1002/anie.202202302

Spontaneous Membranization in a Silk-Based Coacervate Protocell Model

Zhuping Yin, Liangfei Tian, Avinash J Patil, Mei Li, Stephen Mann

Research output: Contribution to journal › Article (Academic Journal) › peer-review

19 Citations (Scopus)

Abstract

A dynamic alginate/silk coacervate-based protocell model capable of reversible reconfigurations between semipermeable coacervate vesicles and membrane-less coacervate droplets is described. Membranization can be reversibly controlled by compositional changes or chemical/enzymatic pH manipulation to adjust the alginate/silk charge ratio. These results open new perspectives in the design of hybrid protocell models with dynamical structural properties.

Original language	English
Journal	Angewandte Chemie - International Edition
Early online date	26 Feb 2022
DOIs	https://doi.org/10.1002/anie.202202302
Publication status	Published - 2022

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Bristol BioDesign Institute
Max Planck Bristol

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10.1002/anie.202202302Licence: CC BY

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title = "Spontaneous Membranization in a Silk-Based Coacervate Protocell Model",

abstract = "A dynamic alginate/silk coacervate-based protocell model capable of reversible reconfigurations between semipermeable coacervate vesicles and membrane-less coacervate droplets is described. Membranization can be reversibly controlled by compositional changes or chemical/enzymatic pH manipulation to adjust the alginate/silk charge ratio. These results open new perspectives in the design of hybrid protocell models with dynamical structural properties.",

author = "Zhuping Yin and Liangfei Tian and Patil, {Avinash J} and Mei Li and Stephen Mann",

year = "2022",

doi = "10.1002/anie.202202302",

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journal = "Angewandte Chemie - International Edition",

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T1 - Spontaneous Membranization in a Silk-Based Coacervate Protocell Model

AU - Yin, Zhuping

AU - Tian, Liangfei

AU - Patil, Avinash J

AU - Li, Mei

AU - Mann, Stephen

PY - 2022

Y1 - 2022

N2 - A dynamic alginate/silk coacervate-based protocell model capable of reversible reconfigurations between semipermeable coacervate vesicles and membrane-less coacervate droplets is described. Membranization can be reversibly controlled by compositional changes or chemical/enzymatic pH manipulation to adjust the alginate/silk charge ratio. These results open new perspectives in the design of hybrid protocell models with dynamical structural properties.

AB - A dynamic alginate/silk coacervate-based protocell model capable of reversible reconfigurations between semipermeable coacervate vesicles and membrane-less coacervate droplets is described. Membranization can be reversibly controlled by compositional changes or chemical/enzymatic pH manipulation to adjust the alginate/silk charge ratio. These results open new perspectives in the design of hybrid protocell models with dynamical structural properties.

U2 - 10.1002/anie.202202302

DO - 10.1002/anie.202202302

M3 - Article (Academic Journal)

C2 - 35176203

SN - 1433-7851

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

ER -

Spontaneous Membranization in a Silk-Based Coacervate Protocell Model

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