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Squamous cell carcinoma of the nasal cavity: A descriptive analysis of cases from the Head and Neck 5000 study

Research output: Contribution to journalArticle

Original languageEnglish
JournalClinical Otolaryngology
Early online date12 Sep 2019
DOIs
DateAccepted/In press - 28 Jul 2019
DateE-pub ahead of print (current) - 12 Sep 2019

Abstract

OBJECTIVES: This paper aims to provide contemporary epidemiological data on squamous cell carcinoma (SCC) of the nasal cavity, which represents a rare type of head and neck cancer.

DESIGN, SETTING & PARTICIPANTS: A descriptive analysis of people with nasal cavity SCC treated with curative intent from the Head and Neck 5000 study; a multicentre clinical cohort study of people from the UK with head and neck cancer. People with tumours of the nasopharynx, paranasal sinuses and other sub-sites of the head and neck were excluded.

MAIN OUTCOME MEASURES: Demographic data and treatment details are presented for all participants. The main outcomes were overall survival and survival according to categories of characteristics (e.g. smoker vs non-smoker); these were explored using Kaplan-Meier plots.

RESULTS: Thirty people with nasal cavity SCC were included in the study, of which most were male (67%) and current or ex-smokers (70%). The majority (70%) presented with early stage (T1/2, N0) tumours. Cervical lymph node metastases at presentation were rare, occurring in only one person. Nine people died during the follow up period (30%). Worse survival outcomes were seen in people with moderate or severe co-morbidities.

CONCLUSIONS: This paper provides epidemiological data on nasal cavity SCC in the UK. Patterns of disease and survival outcomes are described, identifying high-risk groups. Further studies should explore whether primary treatment modality alters survival. This article is protected by copyright. All rights reserved.

Additional information

This article is protected by copyright. All rights reserved.

    Research areas

  • epidemiology, nasal cavity, nasal mucosa, nasal septum, nasal surgical procedures, nose neoplasms, radiation, squamous cell carcinoma

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  • Full-text PDF (author’s accepted manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://doi.org/10.1111/coa.13414 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 198 KB, PDF document

    Embargo ends: 12/09/20

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  • Supplementary information PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://doi.org/10.1111/coa.13414 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 151 KB, PDF document

    Embargo ends: 12/09/20

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