Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer-nucleotide coacervate droplets

John Crosby; Tom Treadwell; Michelle Hammerton; Konstantinos Vasilakis; Matthew P Crump; David S Williams; Stephen Mann

doi:10.1039/c2cc36533b

Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer-nucleotide coacervate droplets

John Crosby^*, Tom Treadwell, Michelle Hammerton, Konstantinos Vasilakis, Matthew P Crump, David S Williams, Stephen Mann

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

89 Citations (Scopus)

Abstract

Compartmentalization of the minimal complex of actinorhodin polyketide synthase in coacervate liquid droplets produces enhanced yields of shunt polyketides under conditions of low and high ionic strength.

Original language	English
Pages (from-to)	11832-11834
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	97
DOIs	https://doi.org/10.1039/c2cc36533b
Publication status	Published - 2012

Keywords

ACYL CARRIER PROTEIN
AROMATIC POLYKETIDES
BIOSYNTHESIS

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http://pubs.rsc.org/en/Content/ArticleLanding/2012/CC/c2cc36533b

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title = "Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer-nucleotide coacervate droplets",

abstract = "Compartmentalization of the minimal complex of actinorhodin polyketide synthase in coacervate liquid droplets produces enhanced yields of shunt polyketides under conditions of low and high ionic strength.",

keywords = "ACYL CARRIER PROTEIN, AROMATIC POLYKETIDES, BIOSYNTHESIS",

author = "John Crosby and Tom Treadwell and Michelle Hammerton and Konstantinos Vasilakis and Crump, {Matthew P} and Williams, {David S} and Stephen Mann",

year = "2012",

doi = "10.1039/c2cc36533b",

language = "English",

volume = "48",

pages = "11832--11834",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "97",

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TY - JOUR

T1 - Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer-nucleotide coacervate droplets

AU - Crosby, John

AU - Treadwell, Tom

AU - Hammerton, Michelle

AU - Vasilakis, Konstantinos

AU - Crump, Matthew P

AU - Williams, David S

AU - Mann, Stephen

PY - 2012

Y1 - 2012

N2 - Compartmentalization of the minimal complex of actinorhodin polyketide synthase in coacervate liquid droplets produces enhanced yields of shunt polyketides under conditions of low and high ionic strength.

AB - Compartmentalization of the minimal complex of actinorhodin polyketide synthase in coacervate liquid droplets produces enhanced yields of shunt polyketides under conditions of low and high ionic strength.

KW - ACYL CARRIER PROTEIN

KW - AROMATIC POLYKETIDES

KW - BIOSYNTHESIS

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84870040718&partnerID=8YFLogxK

U2 - 10.1039/c2cc36533b

DO - 10.1039/c2cc36533b

M3 - Article (Academic Journal)

C2 - 23099989

SN - 1359-7345

VL - 48

SP - 11832

EP - 11834

JO - Chemical Communications

JF - Chemical Communications

IS - 97

ER -

Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer-nucleotide coacervate droplets

Abstract

Keywords

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