Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

Annie Herbert, Matthew E Barclay, Minjoung M Koo, Brian Rous, David C Greenberg, Gary Abel, Georgios Lyratzopoulos*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)
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To determine stage-specific time-trends in renal cancer incidence.

We used population-based East Anglia data 1999−2016 (population ∼2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.

Renal cancer incidence increased from 9.8–16.4 cases per 100,000 during 1999−2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07–1.12) during 1999−2010; and 1.03 (1.00–1.05) during 2011−2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98–1.00) during 2003−2016.

The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.
Original languageEnglish
Article number101883
Pages (from-to)5
Number of pages4
JournalCancer Epidemiology
Issue numberA
Early online date22 Jan 2021
Publication statusPublished - 1 Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors


  • renal
  • cancer
  • stage
  • diagnosis
  • trends


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