Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

Annie Herbert; Matthew E Barclay; Minjoung M Koo; Brian Rous; David C Greenberg; Gary Abel; Georgios Lyratzopoulos

doi:10.1016/j.canep.2020.101883

Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

Annie Herbert
, Matthew E Barclay
, Minjoung M Koo
, Brian Rous
, David C Greenberg
, Gary Abel
, Georgios Lyratzopoulos^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

8 Citations (Scopus)

97 Downloads (Pure)

Abstract

Objectives
To determine stage-specific time-trends in renal cancer incidence.

Methods
We used population-based East Anglia data 1999−2016 (population ∼2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.

Results
Renal cancer incidence increased from 9.8–16.4 cases per 100,000 during 1999−2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07–1.12) during 1999−2010; and 1.03 (1.00–1.05) during 2011−2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98–1.00) during 2003−2016.

Conclusion
The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.

Original language	English
Article number	101883
Pages (from-to)	5
Number of pages	4
Journal	Cancer Epidemiology
Volume	71
Issue number	A
Early online date	22 Jan 2021
DOIs	https://doi.org/10.1016/j.canep.2020.101883
Publication status	Published - 1 Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

renal
cancer
stage
diagnosis
trends

Access to Document

10.1016/j.canep.2020.101883

Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via Elsevier at https://www.sciencedirect.com/science/article/pii/S1877782120302174 . Please refer to any applicable terms of use of the publisher.
Final published version, 864 KBLicence: CC BY

Handle.net

Persistent link

Embargoed Document

Full-text PDF (author’s accepted manuscript)
Accepted author manuscript, 410 KB
Request copy

Embargoed Document

Supplementary information PDF
Accepted author manuscript, 352 KB
Request copy

Cite this

@article{16889c187e6b4e1e936c4faaa7557bb9,

title = "Stage{\textendash}specific incidence trends of renal cancers in the East of England, 1999{\textendash}2016",

abstract = "Objectives To determine stage-specific time-trends in renal cancer incidence. Methods We used population-based East Anglia data 1999−2016 (population ∼2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation. Results Renal cancer incidence increased from 9.8{\textendash}16.4 cases per 100,000 during 1999−2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 \% CI 1.07{\textendash}1.12) during 1999−2010; and 1.03 (1.00{\textendash}1.05) during 2011−2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98{\textendash}1.00) during 2003−2016. Conclusion The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.",

keywords = "renal, cancer, stage, diagnosis, trends",

author = "Annie Herbert and Barclay, \{Matthew E\} and Koo, \{Minjoung M\} and Brian Rous and Greenberg, \{David C\} and Gary Abel and Georgios Lyratzopoulos",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = apr,

day = "1",

doi = "10.1016/j.canep.2020.101883",

language = "English",

volume = "71",

pages = "5",

journal = "Cancer Epidemiology",

issn = "1877-7821",

publisher = "Elsevier Limited",

number = "A",

}

TY - JOUR

T1 - Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

AU - Herbert, Annie

AU - Barclay, Matthew E

AU - Koo, Minjoung M

AU - Rous, Brian

AU - Greenberg, David C

AU - Abel, Gary

AU - Lyratzopoulos, Georgios

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Objectives To determine stage-specific time-trends in renal cancer incidence. Methods We used population-based East Anglia data 1999−2016 (population ∼2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation. Results Renal cancer incidence increased from 9.8–16.4 cases per 100,000 during 1999−2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07–1.12) during 1999−2010; and 1.03 (1.00–1.05) during 2011−2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98–1.00) during 2003−2016. Conclusion The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.

AB - Objectives To determine stage-specific time-trends in renal cancer incidence. Methods We used population-based East Anglia data 1999−2016 (population ∼2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation. Results Renal cancer incidence increased from 9.8–16.4 cases per 100,000 during 1999−2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07–1.12) during 1999−2010; and 1.03 (1.00–1.05) during 2011−2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98–1.00) during 2003−2016. Conclusion The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.

KW - renal

KW - cancer

KW - stage

KW - diagnosis

KW - trends

U2 - 10.1016/j.canep.2020.101883

DO - 10.1016/j.canep.2020.101883

M3 - Article (Academic Journal)

C2 - 33493782

SN - 1877-7821

VL - 71

SP - 5

JO - Cancer Epidemiology

JF - Cancer Epidemiology

IS - A

M1 - 101883

ER -

Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

Handle.net

Embargoed Document

Embargoed Document

Fingerprint

Cite this