Statin pleiotropism and atherosclerotic plaque rupture

CL Jackson; JL Johnson

doi:10.1016/j.atherosclerosis.2009.03.050

Statin pleiotropism and atherosclerotic plaque rupture

CL Jackson, JL Johnson

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2 Citations (Scopus)

Abstract

To be attributed with pleiotropism, statins need to show effects that are unrelated to plasma lipid lowering. In the studies of Nakamura et al. using fluvastatin, it is not clear that this was unequivocally the case. Furthermore, the observed effects of fluvastatin treatment on plaque stability may have been distorted by a potential effect of the drug on fibrinolysis. We conclude that more studies are required before it will be possible to say that fluvastatin influences plaque stability in this mouse model through a non-lipid-lowering mechanism.

Translated title of the contribution	Statin pleiotropism and atherosclerotic plaque rupture
Original language	English
Pages (from-to)	353 - 354
Number of pages	2
Journal	Atherosclerosis
Volume	206(2)
DOIs	https://doi.org/10.1016/j.atherosclerosis.2009.03.050
Publication status	Published - Oct 2009

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Publisher: Elsevier

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10.1016/j.atherosclerosis.2009.03.050

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T12-4W1SRSP-1&_user=121739&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010018&_version=1&_urlVersion=0&_userid=121739&md5=106d308d6191e158bbb637d72390e834

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title = "Statin pleiotropism and atherosclerotic plaque rupture",

abstract = "To be attributed with pleiotropism, statins need to show effects that are unrelated to plasma lipid lowering. In the studies of Nakamura et al. using fluvastatin, it is not clear that this was unequivocally the case. Furthermore, the observed effects of fluvastatin treatment on plaque stability may have been distorted by a potential effect of the drug on fibrinolysis. We conclude that more studies are required before it will be possible to say that fluvastatin influences plaque stability in this mouse model through a non-lipid-lowering mechanism.",

author = "CL Jackson and JL Johnson",

note = "Publisher: Elsevier",

year = "2009",

month = oct,

doi = "10.1016/j.atherosclerosis.2009.03.050",

language = "English",

volume = "206(2)",

pages = "353 -- 354",

journal = "Atherosclerosis",

issn = "1879-1484",

publisher = "Elsevier",

}

TY - JOUR

T1 - Statin pleiotropism and atherosclerotic plaque rupture

AU - Jackson, CL

AU - Johnson, JL

N1 - Publisher: Elsevier

PY - 2009/10

Y1 - 2009/10

N2 - To be attributed with pleiotropism, statins need to show effects that are unrelated to plasma lipid lowering. In the studies of Nakamura et al. using fluvastatin, it is not clear that this was unequivocally the case. Furthermore, the observed effects of fluvastatin treatment on plaque stability may have been distorted by a potential effect of the drug on fibrinolysis. We conclude that more studies are required before it will be possible to say that fluvastatin influences plaque stability in this mouse model through a non-lipid-lowering mechanism.

AB - To be attributed with pleiotropism, statins need to show effects that are unrelated to plasma lipid lowering. In the studies of Nakamura et al. using fluvastatin, it is not clear that this was unequivocally the case. Furthermore, the observed effects of fluvastatin treatment on plaque stability may have been distorted by a potential effect of the drug on fibrinolysis. We conclude that more studies are required before it will be possible to say that fluvastatin influences plaque stability in this mouse model through a non-lipid-lowering mechanism.

U2 - 10.1016/j.atherosclerosis.2009.03.050

DO - 10.1016/j.atherosclerosis.2009.03.050

M3 - Article (Academic Journal)

SN - 1879-1484

VL - 206(2)

SP - 353

EP - 354

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Statin pleiotropism and atherosclerotic plaque rupture

Abstract

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