Projects per year
Living cells sense and process environmental cues through noisy biochemical mechanisms. This apparatus limits the scope of engineering cells as viable sensors. Here, we highlight a mechanism that enables robust, population-wide responses to external stimulation based on cellular communication, known as quorum sensing. We propose a synthetic circuit consisting of two mutually repressing quorum sensing modules. At low cell densities the system behaves like a genetic toggle switch, while at higher cell densities the behaviour of nearby cells is coupled via diffusible quorum sensing molecules. We show by systematic coarse graining that at large length and timescales that the system can be described using the Ising model of a ferromagnet. Thus, in analogy with magnetic systems, the sensitivity of the population-wide response, or its ‘susceptibility’ to a change in the external signal, is highly enhanced for a narrow range of cell-cell coupling close to a critical value. We expect that our approach will be used to enhance the sensitivity of synthetic bio-sensing networks.
|Number of pages||14|
|Journal||Journal of Statistical Mechanics: Theory and Experiment|
|Early online date||9 Mar 2017|
|Publication status||Published - Mar 2017|
- Bristol BioDesign Institute
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- 1 Finished
Computational Approaches to In Vivo Cell Signalling: Inference, Network Structure and Dynamic Decision-Making
15/04/13 → 15/04/16