Steep differences in wingless signaling trigger Myc-independent competitive cell interactions

Jean-Paul Vincent, Golnar Kolahgar, Maria Gagliardi, Eugenia Piddini

Research output: Contribution to journalArticle (Academic Journal)peer-review

82 Citations (Scopus)

Abstract

Wnt signaling is a key regulator of development that is often associated with cancer. Wingless, a Drosophila Wnt homolog, has been reported to be a survival factor in wing imaginal discs. However, we found that prospective wing cells survive in the absence of Wingless as long as they are not surrounded by Wingless-responding cells. Moreover, local autonomous overactivation of Wg signaling (as a result of a mutation in APC or axin) leads to the elimination of surrounding normal cells. Therefore, relative differences in Wingless signaling lead to competitive cell interactions. This process does not involve Myc, a well-established cell competition factor. It does, however, require Notum, a conserved secreted feedback inhibitor of Wnt signaling. We suggest that Notum could amplify local differences in Wingless signaling, thus serving as an early trigger of Wg signaling-dependent competition.

Original languageEnglish
Pages (from-to)366-74
Number of pages9
JournalDevelopmental Cell
Volume21
Issue number2
DOIs
Publication statusPublished - 16 Aug 2011

Keywords

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Animals, Genetically Modified
  • Axin Protein
  • Body Patterning
  • Caspase 3
  • Cell Communication
  • Cell Survival
  • Drosophila
  • Drosophila Proteins
  • Gene Expression Regulation, Developmental
  • Green Fluorescent Proteins
  • Homeodomain Proteins
  • Models, Biological
  • Mutation
  • Proto-Oncogene Proteins c-myc
  • Repressor Proteins
  • Signal Transduction
  • Trans-Activators
  • Transcription Factors
  • Wnt Proteins
  • Journal Article
  • Research Support, Non-U.S. Gov't

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