Stereo- and Regiocontrolled Methylboration of Terminal Alkynes

Oleksandr Zhurakovskyi, Rafael M.P. Dias, Adam Noble, Varinder K. Aggarwal*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)
379 Downloads (Pure)


A scalable and operationally simple synthesis of trisubstituted alkenyl boronic esters has been achieved using a Zr-catalyzed carboalumination of terminal alkynes followed by in situ transmetalation with i-PrOBpin. The products are formed in good yields and with excellent regioselectivity and perfect stereoselectivity. The new procedure provides a significant improvement over the previously reported syntheses.

Original languageEnglish
Pages (from-to)3136-3139
Number of pages4
JournalOrganic Letters
Issue number10
Early online date9 May 2018
Publication statusPublished - 18 May 2018


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