Projects per year
Lithiation/borylation methodology has been developed for the synthesis of acyclic quaternary-tertiary motifs with full control of relative and absolute stereochemistry, thus leading to all four possible isomers of a stereodiad. A novel intramolecular Zweifel-type olefination enabled acyclic stereocontrol to be transformed into cyclic stereocontrol. These key steps have been applied to the shortest enantioselective synthesis of (-)-filiformin to date (9 steps) with full stereocontrol.
- natural products
- total synthesis
- REAGENT-CONTROLLED HOMOLOGATION
- BORONIC ESTERS
- SECONDARY ALCOHOLS
- ENANTIOSELECTIVE CONSTRUCTION
- STEREOSELECTIVE CONSTRUCTION
- ELECTROPHILIC SUBSTITUTION
- (+)-SPARTEINE SURROGATE
FingerprintDive into the research topics of 'Stereocontrolled Synthesis of Adjacent Acyclic Quaternary-Tertiary Motifs: Application to a Concise Total Synthesis of (-)-Filiformin'. Together they form a unique fingerprint.
- 1 Finished
Changing the Synthesis Landscape with Boron at the Helm: from Chiral Organometallics to Assembly Line Synthesis
14/05/12 → 13/01/18