Stereoselective remote functionalization via palladium catalyzed redox-relay Heck methodologies

Holly Bonfield, Damien Valette, David Lindsay, Marc Reid

Research output: Contribution to journalArticle (Academic Journal)

Abstract

Exploration of novel, three-dimensional chemical space is of growing interest in the drug discovery community and with this comes the challenge for synthetic chemists to devise new stereoselective methods to introduce chirality in a rapid and efficient manner. This review provides a timely summary of the development of palladium-catalyzed asymmetric redox-relay Heck type processes. These reactions represent an important class of transformation for the selective introduction of remote stereocenters, and have risen to prominence over the past decade. Within this minireview, the vast scope of these transformations will be showcased, alongside application to pharmaceutically relevant chiral building blocks and drug substances. To complement this overview, a mechanistic summary and discussion of the current limitations of the transformation are presented, followed by an outlook on future areas of investigation.
Original languageUndefined/Unknown
JournalChemistry - A European Journal
DOIs
Publication statusPublished - 3 Aug 2020

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