Stereoselective synthesis of trans-beta-lactams by palladium-catalysed carbonylation of vinyl aziridines

Francesco Fontana, Gian Cesare Tron, Nekane Barbero, Serena Ferrini, Stephen P. Thomas, Varinder K. Aggarwal*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

41 Citations (Scopus)

Abstract

The palladium-catalysed carbonylation of vinyl aziridines can give either the trans- or cis-beta-lactam preferentially or even the delta-lactam simply by adjusting the reaction parameters ([Pd], [CO], temperature).

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalChemical Communications
Volume46
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • ASYMMETRIC-SYNTHESIS
  • DECARBOXYLATIVE CARBONYLATION
  • THERMODYNAMIC PREFERENCE
  • BUILDING-BLOCKS
  • 3,6-DIHYDRO-1H-PYRIDIN-2-ONES
  • REGIOSELECTIVITY

Fingerprint Dive into the research topics of 'Stereoselective synthesis of trans-beta-lactams by palladium-catalysed carbonylation of vinyl aziridines'. Together they form a unique fingerprint.

Cite this