Stereospecific Coupling of Boronic Esters with N-Heteroaromatic Compounds

Josep Llaveria, Daniele Leonori, Varinder K. Aggarwal*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

73 Citations (Scopus)
266 Downloads (Pure)


A protocol for the stereospecific coupling of chiral secondary and tertiary boronic esters with lithiated N-heteroaromatics is described. The process involves initial boronate complex formation followed by addition of Troc-Cl, which activates the nitrogen and induces 1,2-migration. Oxidative workup furnishes the coupled product with >98% es.

Original languageEnglish
Pages (from-to)10958-10961
Number of pages4
JournalJournal of the American Chemical Society
Issue number34
Early online date21 Aug 2015
Publication statusPublished - 2 Sep 2015

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