Projects per year
The reactivity of boronate complexes which resemble donor–acceptor cyclopropanes is described. The enantioenriched cyclopropyl boronate complexes were shown to undergo concerted 1,2-metalate rearrangement/ring opening upon activation with a Lewis acid. This method provides atom-efficient access to optically active γ-carbonyl boronic esters in moderate to excellent yields with complete enantiospecificity. Furthermore, a three-component variant of the reaction was established through in situ alkylation, and the synthetic utility of the products as chiral building blocks was demonstrated.
FingerprintDive into the research topics of 'Strain Release of Donor–Acceptor Cyclopropyl Boronate Complexes'. Together they form a unique fingerprint.
- 1 Finished
The development of strain-release-driven transformations: 1,2-metallate and semipinacol rearrangement reactionsAuthor: Gregson, C. H. U., 28 Sept 2021
Supervisor: Aggarwal, V. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)File