Strategies to extend the life of saphenous vein grafts

Anita Thomas, Gianni Angelini, Mustafa Zakkar

Research output: Chapter in Book/Report/Conference proceedingChapter in a book


Saphenous veins are widely used to bypass blockages in coronary and peripheral arteries,
but up to 50 % of grafts fail within 10–15 years. This is due to neointimal formation and
vein graft disease, processes involving the proliferation of vascular smooth muscle cells, the
production of extracellular matrix, and superimposed atherosclerosis. Several approaches
aimed at preventing neointimal formation and extending the life of vein grafts have been
devised that have yielded promising results. In this chapter we will briefly summarise the
pathophysiology of vein graft disease and then consider potential interventions to prevent
vein graft failure, such as changes in lifestyle, surgical technique, pharmacological
approaches, external sheaths, and gene or stem cell transfer.
Original languageEnglish
Title of host publicationCoronary Graft Failure
Subtitle of host publicationState of the Art
EditorsIC Tintoiu, MJ Underwood, SP Cook, H Kitabata, A Abbas
Place of PublicationSwitzerland
Number of pages13
ISBN (Print)978-3-319-26515-5
Publication statusPublished - 2016

Structured keywords

  • Centre for Surgical Research


  • vein graft
  • Saphenous Vein
  • vein graft disease
  • vein graft failure
  • gene therapy
  • Coronary artery bypass grafting
  • CABG
  • bypass graft
  • external stent


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