Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

Alice J Bochel; Christopher Williams; Airlie J McCoy; Hans-Jürgen  Hoppe; Ashley J Winter; Ryan D Nicholls; Imre Berger; Matthew P Crump

doi:10.1016/j.str.2020.08.002

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

Alice J Bochel, Christopher Williams, Airlie J McCoy, Hans-Jürgen Hoppe, Ashley J Winter, Ryan D Nicholls, Imre Berger, Matthew P Crump^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Original language	English
Number of pages	19
Journal	Structure
Early online date	1 Sep 2020
DOIs	https://doi.org/10.1016/j.str.2020.08.002
Publication status	E-pub ahead of print - 1 Sep 2020

Structured keywords

Bristol BioDesign Institute

Keywords

X-ray crystallography
CI-MPR
IGF2R
P-type lectin
domain 9
mannose 6-phosphate

Access to Document

10.1016/j.str.2020.08.002

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.str.2020.08.002 . Please refer to any applicable terms of use of the publisher.
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1 Article (Academic Journal)

Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist
Frago, S., Nicholls, R., Strickland, M., Hughes, J., Williams, C., Garner, L., Surakhy, M., Maclean, R., Rezgui, D. A. R., Prince, S., Zaccheo, O., Ebner, D., Sanegre, S., Yu, S., Buffa, F. M., Crump, M. & Hassan, A. B., 17 May 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 20, p. E2766-E2775 11 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Biological NMR Facility
Matthew Crump (Manager) & Craig Butts (Manager)
School of Chemistry
Facility/equipment: Facility

Professor Matthew P Crump
- Matt.Crumpbristol.acuk
- Fundamental Bioscience
- School of Chemistry - Professor of NMR and Structural Biology
- Cancer
- Biological and Archaeological Chemistry
- Spectroscopy and Dynamics
Person: Academic , Member

Cite this

@article{1b47a2c3523d4c65a352bfdc2e079219,

title = "Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9",

keywords = "X-ray crystallography, CI-MPR, IGF2R, P-type lectin, domain 9, mannose 6-phosphate",

author = "Bochel, {Alice J} and Christopher Williams and McCoy, {Airlie J} and Hans-J{\"u}rgen Hoppe and Winter, {Ashley J} and Nicholls, {Ryan D} and Imre Berger and Crump, {Matthew P}",

year = "2020",

month = sep,

day = "1",

doi = "10.1016/j.str.2020.08.002",

language = "English",

journal = "Structure",

issn = "0969-2126",

publisher = "Cell Press",

}

TY - JOUR

T1 - Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

AU - Bochel, Alice J

AU - Williams, Christopher

AU - McCoy, Airlie J

AU - Hoppe, Hans-Jürgen

AU - Winter, Ashley J

AU - Nicholls, Ryan D

AU - Berger, Imre

AU - Crump, Matthew P

PY - 2020/9/1

Y1 - 2020/9/1

KW - X-ray crystallography

KW - CI-MPR

KW - IGF2R

KW - P-type lectin

KW - domain 9

KW - mannose 6-phosphate

U2 - 10.1016/j.str.2020.08.002

DO - 10.1016/j.str.2020.08.002

M3 - Article (Academic Journal)

C2 - 32877646

JO - Structure

JF - Structure

SN - 0969-2126

ER -

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

Structured keywords

Keywords

Access to Document

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Research output

Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

Equipment

Biological NMR Facility

Profiles

Professor Matthew P Crump

Cite this