Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

Alice J Bochel; Christopher Williams; Airlie J McCoy; Hans-Jürgen  Hoppe; Ashley J Winter; Ryan D Nicholls; Imre Berger; Matthew P Crump

doi:10.1016/j.str.2020.08.002

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

Alice J Bochel, Christopher Williams, Airlie J McCoy, Hans-Jürgen Hoppe, Ashley J Winter, Ryan D Nicholls, Imre Berger, Matthew P Crump^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

12 Citations (Scopus)

148 Downloads (Pure)

Original language	English
Number of pages	19
Journal	Structure
Early online date	1 Sept 2020
DOIs	https://doi.org/10.1016/j.str.2020.08.002
Publication status	E-pub ahead of print - 1 Sept 2020

Research Groups and Themes

Bristol BioDesign Institute
Organic & Biological

Keywords

P-type lectin
synthetic biology
CI-MPR
X-ray crystallography
mannose 6-phosphate
IGF2R
domain 9

Access to Document

10.1016/j.str.2020.08.002

Full-text PDF (author’s accepted manuscript)
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.str.2020.08.002 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 4.79 MBLicence: CC BY-NC-ND

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12 Citations
1 Article (Academic Journal)

Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist
Frago, S., Nicholls, R., Strickland, M., Hughes, J., Williams, C., Garner, L., Surakhy, M., Maclean, R., Rezgui, D. A. R., Prince, S., Zaccheo, O., Ebner, D., Sanegre, S., Yu, S., Buffa, F. M., Crump, M. & Hassan, A. B., 17 May 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 20, p. E2766-E2775 11 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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23 Citations (Scopus)

482 Downloads (Pure)

Biological NMR Facility
Crump, M. (Manager) & Butts, C. (Manager)
School of Chemistry
Facility/equipment: Facility

Professor Matthew P Crump
- Matt.Crumpbristol.acuk
- School of Chemistry - Professor of NMR and Structural Biology
- Cancer
Person: Academic , Member

Cite this

@article{1b47a2c3523d4c65a352bfdc2e079219,

title = "Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9",

keywords = "P-type lectin, synthetic biology, CI-MPR, X-ray crystallography, mannose 6-phosphate, IGF2R, domain 9",

author = "Bochel, \{Alice J\} and Christopher Williams and McCoy, \{Airlie J\} and Hans-J{\"u}rgen Hoppe and Winter, \{Ashley J\} and Nicholls, \{Ryan D\} and Imre Berger and Crump, \{Matthew P\}",

year = "2020",

month = sep,

day = "1",

doi = "10.1016/j.str.2020.08.002",

language = "English",

journal = "Structure",

issn = "0969-2126",

publisher = "Cell Press",

}

TY - JOUR

T1 - Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

AU - Bochel, Alice J

AU - Williams, Christopher

AU - McCoy, Airlie J

AU - Hoppe, Hans-Jürgen

AU - Winter, Ashley J

AU - Nicholls, Ryan D

AU - Berger, Imre

AU - Crump, Matthew P

PY - 2020/9/1

Y1 - 2020/9/1

KW - P-type lectin

KW - synthetic biology

KW - CI-MPR

KW - X-ray crystallography

KW - mannose 6-phosphate

KW - IGF2R

KW - domain 9

U2 - 10.1016/j.str.2020.08.002

DO - 10.1016/j.str.2020.08.002

M3 - Article (Academic Journal)

C2 - 32877646

SN - 0969-2126

JO - Structure

JF - Structure

ER -

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

Research Groups and Themes

Keywords

Access to Document

Handle.net

Research output

Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

Equipment

Biological NMR Facility

Profiles

Professor Matthew P Crump

Cite this