Studying the role of axon fasciculation during development in a computational model of the Xenopus tadpole spinal cord

Oliver Davis, Robert Merrison-Hort*, Stephen R. Soffe, Roman Borisyuk

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
235 Downloads (Pure)

Abstract

During nervous system development growing axons can interact with each other, for example by adhering together in order to produce bundles (fasciculation). How does such axon-axon interaction affect the resulting axonal trajectories, and what are the possible benefits of this process in terms of network function? In this paper we study these questions by adapting an existing computational model of the development of neurons in the Xenopus tadpole spinal cord to include interactions between axons. We demonstrate that even relatively weak attraction causes bundles to appear, while if axons weakly repulse each other their trajectories diverge such that they fill the available space. We show how fasciculation can help to ensure axons grow in the correct location for proper network formation when normal growth barriers contain gaps, and use a functional spiking model to show that fasciculation allows the network to generate reliable swimming behaviour even when overall synapse counts are artificially lowered. Although we study fasciculation in one particular organism, our approach to modelling axon growth is general and can be widely applied to study other nervous systems.

Original languageEnglish
Article number13551
JournalScientific Reports
Volume7
Early online date19 Oct 2017
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint Dive into the research topics of 'Studying the role of axon fasciculation during development in a computational model of the Xenopus tadpole spinal cord'. Together they form a unique fingerprint.

  • Projects

    Cite this