Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates

B Strohm; A Hobson; P Brocklehurst; AD Edwards; M Thoresen; SS Cherian; L Miall; M Chandrasekaran; A Quadri; M Kumar; T Austin; H O'Reilly; M Murphy; A Moore; N Tusor; G Pelligra; D Azzopardi

doi:10.1542/peds.2010-3508

Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates

B Strohm, A Hobson, P Brocklehurst, AD Edwards, M Thoresen, SS Cherian, L Miall, M Chandrasekaran, A Quadri, M Kumar, T Austin, H O'Reilly, M Murphy, A Moore, N Tusor, G Pelligra, D Azzopardi

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Abstract

Therapeutic moderate hypothermia in newborns with hypoxic-ischemic encephalopathy is rapidly becoming standard clinical practice. We report here 12 cases of subcutaneous fat necrosis among 1239 cases registered with a national registry of newborns treated with moderate whole-body hypothermia. All the infants suffered from perinatal asphyxia and hypoxic-ischemic encephalopathy. Moderate-to-severe hypercalcemia was identified in 8 of 10 infants with blood calcium measurements. In all cases the skin lesions appeared after completion of the cooling treatment. Our data suggest that prolonged moderate hypothermia is an actual risk factor for subcutaneous fat necrosis. Because the lesions often develop several days after birth, physicians need to be aware of this condition as a possible complication in infants treated with moderate hypothermia after asphyxia. Blood calcium levels need to be monitored in affected infants.

Translated title of the contribution	Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates
Original language	English
Article number	e-pub 4 July 2011
Pages (from-to)	e450 - e452
Number of pages	3
Journal	Pediatrics
Volume	128 (2)
DOIs	https://doi.org/10.1542/peds.2010-3508
Publication status	Published - Aug 2011

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Strohm, B., Hobson, A., Brocklehurst, P., Edwards, AD., Thoresen, M., Cherian, SS., Miall, L., Chandrasekaran, M., Quadri, A., Kumar, M., Austin, T., O'Reilly, H., Murphy, M., Moore, A., Tusor, N., Pelligra, G., & Azzopardi, D. (2011). Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates. Pediatrics, 128 (2), e450 - e452. Article e-pub 4 July 2011. https://doi.org/10.1542/peds.2010-3508

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title = "Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates",

abstract = "Therapeutic moderate hypothermia in newborns with hypoxic-ischemic encephalopathy is rapidly becoming standard clinical practice. We report here 12 cases of subcutaneous fat necrosis among 1239 cases registered with a national registry of newborns treated with moderate whole-body hypothermia. All the infants suffered from perinatal asphyxia and hypoxic-ischemic encephalopathy. Moderate-to-severe hypercalcemia was identified in 8 of 10 infants with blood calcium measurements. In all cases the skin lesions appeared after completion of the cooling treatment. Our data suggest that prolonged moderate hypothermia is an actual risk factor for subcutaneous fat necrosis. Because the lesions often develop several days after birth, physicians need to be aware of this condition as a possible complication in infants treated with moderate hypothermia after asphyxia. Blood calcium levels need to be monitored in affected infants.",

author = "B Strohm and A Hobson and P Brocklehurst and AD Edwards and M Thoresen and SS Cherian and L Miall and M Chandrasekaran and A Quadri and M Kumar and T Austin and H O'Reilly and M Murphy and A Moore and N Tusor and G Pelligra and D Azzopardi",

year = "2011",

month = aug,

doi = "10.1542/peds.2010-3508",

language = "English",

volume = "128 (2)",

pages = "e450 -- e452",

journal = "Pediatrics",

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publisher = "American Academy of Pediatrics",

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Strohm, B, Hobson, A, Brocklehurst, P, Edwards, AD, Thoresen, M, Cherian, SS, Miall, L, Chandrasekaran, M, Quadri, A, Kumar, M, Austin, T, O'Reilly, H, Murphy, M, Moore, A, Tusor, N, Pelligra, G & Azzopardi, D 2011, 'Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates', Pediatrics, vol. 128 (2), e-pub 4 July 2011, pp. e450 - e452. https://doi.org/10.1542/peds.2010-3508

TY - JOUR

T1 - Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates

AU - Strohm, B

AU - Hobson, A

AU - Brocklehurst, P

AU - Edwards, AD

AU - Thoresen, M

AU - Cherian, SS

AU - Miall, L

AU - Chandrasekaran, M

AU - Quadri, A

AU - Kumar, M

AU - Austin, T

AU - O'Reilly, H

AU - Murphy, M

AU - Moore, A

AU - Tusor, N

AU - Pelligra, G

AU - Azzopardi, D

PY - 2011/8

Y1 - 2011/8

N2 - Therapeutic moderate hypothermia in newborns with hypoxic-ischemic encephalopathy is rapidly becoming standard clinical practice. We report here 12 cases of subcutaneous fat necrosis among 1239 cases registered with a national registry of newborns treated with moderate whole-body hypothermia. All the infants suffered from perinatal asphyxia and hypoxic-ischemic encephalopathy. Moderate-to-severe hypercalcemia was identified in 8 of 10 infants with blood calcium measurements. In all cases the skin lesions appeared after completion of the cooling treatment. Our data suggest that prolonged moderate hypothermia is an actual risk factor for subcutaneous fat necrosis. Because the lesions often develop several days after birth, physicians need to be aware of this condition as a possible complication in infants treated with moderate hypothermia after asphyxia. Blood calcium levels need to be monitored in affected infants.

AB - Therapeutic moderate hypothermia in newborns with hypoxic-ischemic encephalopathy is rapidly becoming standard clinical practice. We report here 12 cases of subcutaneous fat necrosis among 1239 cases registered with a national registry of newborns treated with moderate whole-body hypothermia. All the infants suffered from perinatal asphyxia and hypoxic-ischemic encephalopathy. Moderate-to-severe hypercalcemia was identified in 8 of 10 infants with blood calcium measurements. In all cases the skin lesions appeared after completion of the cooling treatment. Our data suggest that prolonged moderate hypothermia is an actual risk factor for subcutaneous fat necrosis. Because the lesions often develop several days after birth, physicians need to be aware of this condition as a possible complication in infants treated with moderate hypothermia after asphyxia. Blood calcium levels need to be monitored in affected infants.

U2 - 10.1542/peds.2010-3508

DO - 10.1542/peds.2010-3508

M3 - Article (Academic Journal)

C2 - 21727110

SN - 1098-4275

VL - 128 (2)

SP - e450 - e452

JO - Pediatrics

JF - Pediatrics

M1 - e-pub 4 July 2011

ER -

Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates

Abstract

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