Subcutaneous pulsatile glucocorticoid replacement therapy

Georgina M Russell, Claire Durant, Alia Ataya, Chrysoula Papastathi, Ragini Bhake, Wolfram Woltersdorf, Stafford Lightman

Research output: Contribution to journalArticle (Academic Journal)peer-review

37 Citations (Scopus)


The glucocorticoid hormone cortisol is released in pulses resulting in a complex and dynamic ultradian rhythm of plasma cortisol that underlies the classical circadian rhythm. These oscillating levels are also seen at the level of tissues such as the brain and trigger pulses of gene activation and downstream signalling. Different patterns of glucocorticoid presentation (constant versus pulsatile) result not only in different patterns of gene regulation but also different neuroendocrine and behavioural responses. Current "optimal" glucocorticoid replacement therapy results in smooth hormone blood levels and does not replicate physiological pulsatile cortisol secretion. We have now validated a novel portable pulsatile continuous subcutaneous hydrocortisone delivery system in healthy volunteers that more closely replicates the physiological circadian and ultradian rhythmicity. This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)289-93
JournalClinical Endocrinology
Issue number2
Publication statusPublished - 16 Apr 2014

Bibliographical note

This article is protected by copyright. All rights reserved.


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