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Imidazolidinone derivatives of a range of aromatic α-amino acids, on treatment with phosgene and potassium iodide, undergo a mild Bischler-Napieralski-style cyclocarbonylation reaction that generates a tricyclic lactam by insertion of a C=O group between amino acid nitrogen and the ortho position of the aryl substituent. Regio- and diastereoselective functionalization of the lactam generates a library of substituted dihydroisoquinolinones and their congeners in enantioenriched form.
|Number of pages||5|
|Early online date||5 Dec 2018|
|Publication status||Published - 21 Dec 2018|
FingerprintDive into the research topics of 'Substituted Dihydroisoquinolinones by Iodide-Promoted Cyclocarbonylation of Aromatic α-Amino Acids'. Together they form a unique fingerprint.
- 2 Finished
QUATERMAIN - Quaternary amino acids on scale for medicine and agroscience
1/11/16 → 30/04/18
alpha-Arylation and alpha-Vinylation of Enolates: New Reactivity from the Urea Linkage.
1/07/15 → 31/05/18