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Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry Database (ICAD)

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Substituting prolonged sedentary time and cardiovascular risk in children and youth : a meta-analysis within the International Children's Accelerometry Database (ICAD). / Wijndaele, Katrien; White, Thomas; Andersen, Lars Bo; Bugge, Anna; Kolle, Elin; Northstone, Kate; Wedderkopp, Niels; Ried-Larsen, M; Kriemler, Susi; Page, Angie S; Puder , Jardena ; Reilly, John J; Sardinha, Luis B; van Sluijs, EMF; Sharp, Stephen J; Brage, Soren; Ekelund, Ulf.

In: International Journal of Behavioral Nutrition and Physical Activity, Vol. 16, 96 (2019), 31.10.2019.

Research output: Contribution to journalArticle

Harvard

Wijndaele, K, White, T, Andersen, LB, Bugge, A, Kolle, E, Northstone, K, Wedderkopp, N, Ried-Larsen, M, Kriemler, S, Page, AS, Puder , J, Reilly, JJ, Sardinha, LB, van Sluijs, EMF, Sharp, SJ, Brage, S & Ekelund, U 2019, 'Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry Database (ICAD)', International Journal of Behavioral Nutrition and Physical Activity, vol. 16, 96 (2019). https://doi.org/10.1186/s12966-019-0858-6

APA

Wijndaele, K., White, T., Andersen, L. B., Bugge, A., Kolle, E., Northstone, K., ... Ekelund, U. (2019). Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry Database (ICAD). International Journal of Behavioral Nutrition and Physical Activity, 16, [96 (2019)]. https://doi.org/10.1186/s12966-019-0858-6

Vancouver

Wijndaele K, White T, Andersen LB, Bugge A, Kolle E, Northstone K et al. Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry Database (ICAD). International Journal of Behavioral Nutrition and Physical Activity. 2019 Oct 31;16. 96 (2019). https://doi.org/10.1186/s12966-019-0858-6

Author

Wijndaele, Katrien ; White, Thomas ; Andersen, Lars Bo ; Bugge, Anna ; Kolle, Elin ; Northstone, Kate ; Wedderkopp, Niels ; Ried-Larsen, M ; Kriemler, Susi ; Page, Angie S ; Puder , Jardena ; Reilly, John J ; Sardinha, Luis B ; van Sluijs, EMF ; Sharp, Stephen J ; Brage, Soren ; Ekelund, Ulf. / Substituting prolonged sedentary time and cardiovascular risk in children and youth : a meta-analysis within the International Children's Accelerometry Database (ICAD). In: International Journal of Behavioral Nutrition and Physical Activity. 2019 ; Vol. 16.

Bibtex

@article{7f386b081c4d43f780bf76c4d6c641e7,
title = "Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry Database (ICAD)",
abstract = "BackgroundEvidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children.MethodsCross-sectional data from 14 studies (7 countries) in the International Children’s Accelerometry Database (ICAD, 1998–2009) was included. Accelerometry in 19,502 participants aged 3–18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95{\%}CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed.ResultsModelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (− 0.44 (− 0.62; − 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (− 3.07 (− 4.47; − 1.68) cm), systolic blood pressure (− 1.53 (− 2.42; − 0.65) mmHg) and clustered cardio-metabolic risk (− 0.18 (− 0.3; − 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: − 0.81 (− 1.38; − 0.24) mmHg).ConclusionsReplacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.",
keywords = "ICAD, ALSPAC, Prolonged sitting, Cardio-metabolic, Iso-temporal, Physical activity",
author = "Katrien Wijndaele and Thomas White and Andersen, {Lars Bo} and Anna Bugge and Elin Kolle and Kate Northstone and Niels Wedderkopp and M Ried-Larsen and Susi Kriemler and Page, {Angie S} and Jardena Puder and Reilly, {John J} and Sardinha, {Luis B} and {van Sluijs}, EMF and Sharp, {Stephen J} and Soren Brage and Ulf Ekelund",
year = "2019",
month = "10",
day = "31",
doi = "10.1186/s12966-019-0858-6",
language = "English",
volume = "16",
journal = "International Journal of Behavioral Nutrition and Physical Activity",
issn = "1479-5868",
publisher = "BioMed Central",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Substituting prolonged sedentary time and cardiovascular risk in children and youth

T2 - a meta-analysis within the International Children's Accelerometry Database (ICAD)

AU - Wijndaele, Katrien

AU - White, Thomas

AU - Andersen, Lars Bo

AU - Bugge, Anna

AU - Kolle, Elin

AU - Northstone, Kate

AU - Wedderkopp, Niels

AU - Ried-Larsen, M

AU - Kriemler, Susi

AU - Page, Angie S

AU - Puder , Jardena

AU - Reilly, John J

AU - Sardinha, Luis B

AU - van Sluijs, EMF

AU - Sharp, Stephen J

AU - Brage, Soren

AU - Ekelund, Ulf

PY - 2019/10/31

Y1 - 2019/10/31

N2 - BackgroundEvidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children.MethodsCross-sectional data from 14 studies (7 countries) in the International Children’s Accelerometry Database (ICAD, 1998–2009) was included. Accelerometry in 19,502 participants aged 3–18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed.ResultsModelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (− 0.44 (− 0.62; − 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (− 3.07 (− 4.47; − 1.68) cm), systolic blood pressure (− 1.53 (− 2.42; − 0.65) mmHg) and clustered cardio-metabolic risk (− 0.18 (− 0.3; − 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: − 0.81 (− 1.38; − 0.24) mmHg).ConclusionsReplacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.

AB - BackgroundEvidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children.MethodsCross-sectional data from 14 studies (7 countries) in the International Children’s Accelerometry Database (ICAD, 1998–2009) was included. Accelerometry in 19,502 participants aged 3–18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed.ResultsModelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (− 0.44 (− 0.62; − 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (− 3.07 (− 4.47; − 1.68) cm), systolic blood pressure (− 1.53 (− 2.42; − 0.65) mmHg) and clustered cardio-metabolic risk (− 0.18 (− 0.3; − 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: − 0.81 (− 1.38; − 0.24) mmHg).ConclusionsReplacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.

KW - ICAD

KW - ALSPAC

KW - Prolonged sitting

KW - Cardio-metabolic

KW - Iso-temporal

KW - Physical activity

U2 - 10.1186/s12966-019-0858-6

DO - 10.1186/s12966-019-0858-6

M3 - Article

C2 - 31672163

VL - 16

JO - International Journal of Behavioral Nutrition and Physical Activity

JF - International Journal of Behavioral Nutrition and Physical Activity

SN - 1479-5868

M1 - 96 (2019)

ER -