Substrate specificity of strictosidine synthase

E McCoy; MC Galan; SE O'Connor

doi:10.1016/j.bmcl.2006.01.098

Substrate specificity of strictosidine synthase

E McCoy, MC Galan , SE O'Connor

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

82 Citations (Scopus)

Abstract

Strictosidine synthase catalyzes a Pictet–Spengler reaction in the first step in the biosynthesis of terpene indole alkaloids to generate strictosidine. The substrate requirements for strictosidine synthase are systematically and quantitatively examined and the enzymatically generated compounds are processed by the second enzyme in this biosynthetic pathway.

Translated title of the contribution	Substrate specificity of strictosidine synthase
Original language	English
Pages (from-to)	2475 - 2478
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16 (9)
DOIs	https://doi.org/10.1016/j.bmcl.2006.01.098
Publication status	Published - May 2006

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Publisher: Elsevier

Research Groups and Themes

Organic & Biological

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title = "Substrate specificity of strictosidine synthase",

abstract = "Strictosidine synthase catalyzes a Pictet–Spengler reaction in the first step in the biosynthesis of terpene indole alkaloids to generate strictosidine. The substrate requirements for strictosidine synthase are systematically and quantitatively examined and the enzymatically generated compounds are processed by the second enzyme in this biosynthetic pathway.",

author = "E McCoy and MC Galan and SE O'Connor",

note = "Publisher: Elsevier",

year = "2006",

month = may,

doi = "10.1016/j.bmcl.2006.01.098",

language = "English",

volume = "16 (9)",

pages = "2475 -- 2478",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "1464-3405",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Substrate specificity of strictosidine synthase

AU - McCoy, E

AU - Galan , MC

AU - O'Connor, SE

N1 - Publisher: Elsevier

PY - 2006/5

Y1 - 2006/5

N2 - Strictosidine synthase catalyzes a Pictet–Spengler reaction in the first step in the biosynthesis of terpene indole alkaloids to generate strictosidine. The substrate requirements for strictosidine synthase are systematically and quantitatively examined and the enzymatically generated compounds are processed by the second enzyme in this biosynthetic pathway.

AB - Strictosidine synthase catalyzes a Pictet–Spengler reaction in the first step in the biosynthesis of terpene indole alkaloids to generate strictosidine. The substrate requirements for strictosidine synthase are systematically and quantitatively examined and the enzymatically generated compounds are processed by the second enzyme in this biosynthetic pathway.

U2 - 10.1016/j.bmcl.2006.01.098

DO - 10.1016/j.bmcl.2006.01.098

M3 - Article (Academic Journal)

SN - 1464-3405

VL - 16 (9)

SP - 2475

EP - 2478

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

ER -

Substrate specificity of strictosidine synthase

Abstract

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