Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

Ambra Albertario, Megan M Swim, Eltayeb Mohamed Ahmed, Dominga Iacobazzi, Michael Yeong, Paolo Madeddu, Mohamed Ghorbel, Massimo Caputo*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)
156 Downloads (Pure)

Abstract

Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellular grafts. To the authors’ knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model.

Original languageEnglish
Pages (from-to)364-384
Number of pages21
JournalJACC: Basic to Translational Science
Volume4
Issue number3
Early online date24 Jun 2019
DOIs
Publication statusPublished - Jun 2019

Keywords

  • congenital heart disease
  • reconstruction
  • right ventricular outflow swine model
  • tissue engineering
  • tract stem cells

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