Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

Ambra Albertario; Megan M Swim; Eltayeb Mohamed Ahmed; Dominga Iacobazzi; Michael Yeong; Paolo Madeddu; Mohamed Ghorbel; Massimo Caputo

doi:10.1016/j.jacbts.2019.02.001

Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

Ambra Albertario
, Megan M Swim
, Eltayeb Mohamed Ahmed
, Dominga Iacobazzi
, Michael Yeong
, Paolo Madeddu
, Mohamed Ghorbel
, Massimo Caputo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

14 Citations (Scopus)

279 Downloads (Pure)

Abstract

Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellular grafts. To the authors’ knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model.

Original language	English
Pages (from-to)	364-384
Number of pages	21
Journal	JACC: Basic to Translational Science
Volume	4
Issue number	3
Early online date	24 Jun 2019
DOIs	https://doi.org/10.1016/j.jacbts.2019.02.001
Publication status	Published - Jun 2019

Research Groups and Themes

Bristol Heart Institute
congenital heart disease
right ventricular outflow
reconstruction
tract stem cells
tissue engineering

Keywords

congenital heart disease
reconstruction
right ventricular outflow swine model
tissue engineering
tract stem cells

Access to Document

10.1016/j.jacbts.2019.02.001

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title = "Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine",

abstract = "Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellular grafts. To the authors{\textquoteright} knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model.",

keywords = "congenital heart disease, reconstruction, right ventricular outflow swine model, tissue engineering, tract stem cells",

author = "Ambra Albertario and Swim, \{Megan M\} and \{Mohamed Ahmed\}, Eltayeb and Dominga Iacobazzi and Michael Yeong and Paolo Madeddu and Mohamed Ghorbel and Massimo Caputo",

year = "2019",

month = jun,

doi = "10.1016/j.jacbts.2019.02.001",

language = "English",

volume = "4",

pages = "364--384",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier Inc.",

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}

TY - JOUR

T1 - Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

AU - Albertario, Ambra

AU - Swim, Megan M

AU - Mohamed Ahmed, Eltayeb

AU - Iacobazzi, Dominga

AU - Yeong, Michael

AU - Madeddu, Paolo

AU - Ghorbel, Mohamed

AU - Caputo, Massimo

PY - 2019/6

Y1 - 2019/6

N2 - Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellular grafts. To the authors’ knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model.

AB - Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellular grafts. To the authors’ knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model.

KW - congenital heart disease

KW - reconstruction

KW - right ventricular outflow swine model

KW - tissue engineering

KW - tract stem cells

UR - https://www.scopus.com/pages/publications/85067256644

U2 - 10.1016/j.jacbts.2019.02.001

DO - 10.1016/j.jacbts.2019.02.001

M3 - Article (Academic Journal)

C2 - 31312760

AN - SCOPUS:85067256644

SN - 2452-302X

VL - 4

SP - 364

EP - 384

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 3

ER -

Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

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Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

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Research Groups and Themes

Keywords

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Professor Massimo Caputo

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