SUMOylation of synaptic and synapse-associated proteins: An update

Jeremy M Henley; Richard A Seager; Yasuko Nakamura; Karolina Talandyte; Jithin Dhandapani Nair; Kevin A Wilkinson

doi:10.1111/jnc.15103

SUMOylation of synaptic and synapse-associated proteins: An update

Jeremy M Henley^*, Richard A Seager, Yasuko Nakamura, Karolina Talandyte, Jithin Dhandapani Nair, Kevin A Wilkinson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

SUMOylation is a post‐translational modification that regulates protein signalling and complex formation by adjusting the conformation or protein–protein interactions of the substrate protein. There is a compelling and rapidly expanding body of evidence that, in addition to SUMOylation of nuclear proteins, SUMOylation of extranuclear proteins contributes to the control of neuronal development, neuronal stress responses and synaptic transmission and plasticity. In this brief review we provide an update of recent developments in the identification of synaptic and synapse‐associated SUMO target proteins and discuss the cell biological and functional implications of these discoveries.

Original language	English
Number of pages	17
Journal	Journal of Neurochemistry
Early online date	15 Jun 2020
DOIs	https://doi.org/10.1111/jnc.15103
Publication status	E-pub ahead of print - 15 Jun 2020

Keywords

GTPases
ion channels
SUMOylation
synaptic plasticity
synaptic proteins

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Understanding the roles of SUMO proteases in neuronal function and viability
Henley, J. M. (Principal Investigator)
1/07/18 → 30/06/23
Project: Research

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title = "SUMOylation of synaptic and synapse-associated proteins: An update",

abstract = "SUMOylation is a post‐translational modification that regulates protein signalling and complex formation by adjusting the conformation or protein–protein interactions of the substrate protein. There is a compelling and rapidly expanding body of evidence that, in addition to SUMOylation of nuclear proteins, SUMOylation of extranuclear proteins contributes to the control of neuronal development, neuronal stress responses and synaptic transmission and plasticity. In this brief review we provide an update of recent developments in the identification of synaptic and synapse‐associated SUMO target proteins and discuss the cell biological and functional implications of these discoveries.",

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AU - Henley, Jeremy M

AU - Seager, Richard A

AU - Nakamura, Yasuko

AU - Talandyte, Karolina

AU - Dhandapani Nair, Jithin

AU - Wilkinson, Kevin A

PY - 2020/6/15

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AB - SUMOylation is a post‐translational modification that regulates protein signalling and complex formation by adjusting the conformation or protein–protein interactions of the substrate protein. There is a compelling and rapidly expanding body of evidence that, in addition to SUMOylation of nuclear proteins, SUMOylation of extranuclear proteins contributes to the control of neuronal development, neuronal stress responses and synaptic transmission and plasticity. In this brief review we provide an update of recent developments in the identification of synaptic and synapse‐associated SUMO target proteins and discuss the cell biological and functional implications of these discoveries.

KW - GTPases

KW - ion channels

KW - SUMOylation

KW - synaptic plasticity

KW - synaptic proteins

U2 - 10.1111/jnc.15103

DO - 10.1111/jnc.15103

M3 - Article (Academic Journal)

C2 - 32538470

SN - 0022-3042

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

ER -

SUMOylation of synaptic and synapse-associated proteins: An update

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Keywords

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Understanding the roles of SUMO proteases in neuronal function and viability

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