SUMOylation of synaptic and synapse-associated proteins: An update

Jeremy M Henley*, Richard A Seager, Yasuko Nakamura, Karolina Talandyte, Jithin Dhandapani Nair, Kevin A Wilkinson*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

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SUMOylation is a post‐translational modification that regulates protein signalling and complex formation by adjusting the conformation or protein–protein interactions of the substrate protein. There is a compelling and rapidly expanding body of evidence that, in addition to SUMOylation of nuclear proteins, SUMOylation of extranuclear proteins contributes to the control of neuronal development, neuronal stress responses and synaptic transmission and plasticity. In this brief review we provide an update of recent developments in the identification of synaptic and synapse‐associated SUMO target proteins and discuss the cell biological and functional implications of these discoveries.
Original languageEnglish
Number of pages17
JournalJournal of Neurochemistry
Early online date15 Jun 2020
Publication statusE-pub ahead of print - 15 Jun 2020


  • GTPases
  • ion channels
  • SUMOylation
  • synaptic plasticity
  • synaptic proteins

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