Superfamily I helicases as modular components of DNA-processing machines

Research output: Contribution to journalArticle (Academic Journal)peer-review

45 Citations (Scopus)

Abstract

Helicases are a ubiquitous and abundant group of motor proteins that couple NTP binding and hydrolysis to processive unwinding of nucleic acids. By targeting this activity to a wide range of specific substrates, and by coupling it with other catalytic functionality, helicases fulfil diverse roles in virtually all aspects of nucleic acid metabolism. The present review takes a look back at our efforts to elucidate the molecular mechanisms of UvrD-like DNA helicases. Using these well-studied enzymes as examples, we also discuss how helicases are programmed by interactions with partner proteins to participate in specific cellular functions.
Translated title of the contributionSuperfamily I helicase as modular components of DNA-processing machines
Original languageEnglish
Pages (from-to)413 - 423
Number of pages11
JournalBiochemical Society Transactions
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 2011

Bibliographical note

Other: Colworth Medal Lecture

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