Supplementation with a low-moderate dose of n-3 long-chain PUFA has no short-term effect on bone resorption in human adults

K M Appleton, W D Fraser, P J Rogers, A R Ness, J H Tobias

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)

Abstract

Abstract Previous research suggests that n-3 PUFA may play a role in bone health. The present analysis aimed to investigate the impact of n-3 PUFA supplementation on bone resorption in adult men and women. Serum samples from 113 mild-moderately depressed individuals (twenty-six males and eighty-seven females, aged 18-67 years) randomised to receive 1·48 g EPA+DHA/d (n 53) or placebo (n 60) for 12 weeks as part of a large recent randomised controlled trial were assayed for n-3 PUFA status and a bone resorption marker, C-terminal cross-linking telopeptide of type 1 collagen (β-CTX). Regression analyses revealed that n-3 PUFA status following supplementation was associated with randomisation (placebo/n-3 PUFA) (B = 3·25, 95 % CI 2·60, 3·91, P <0·01). However, β-CTX status following supplementation was not associated with randomisation (B = - 0·01, 95 % CI - 0·03, 0·04). Change in β-CTX status was also not associated with change in n-3 PUFA status (B = - 0·002, 95 % CI - 0·01, 0·01). These findings provide no evidence for an association between n-3 PUFA supplementation (1·48 g EPA+DHA/d) for 12 weeks and bone resorption in humans assessed by β-CTX, and suggest that n-3 PUFA supplementation may be unlikely to be of benefit in preventing bone loss.
Translated title of the contributionSupplementation with a low-moderate dose of n-3 long-chain PUFA has no short-term effect on bone resorption in human adults
Original languageEnglish
Pages (from-to)1145 - 1149
Number of pages5
JournalBritish Journal of Nutrition
Volume105
Issue number8
DOIs
Publication statusPublished - Apr 2011

Structured keywords

  • Brain and Behaviour
  • Nutrition and Behaviour

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