Supply chain logistics - the role of the Golgi complex in extracellular matrix production and maintenance

John Hellicar; Nicola L Stevenson; David J Stephens; Martin Lowe

doi:10.1242/jcs.258879

Supply chain logistics - the role of the Golgi complex in extracellular matrix production and maintenance

John Hellicar, Nicola L Stevenson, David J Stephens^*, Martin Lowe^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

23 Citations (Scopus)

199 Downloads (Pure)

Abstract

The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation of the secretory pathway. The Golgi complex plays a vital role in directing matrix output by co-ordinating the post-translational modification and proteolytic processing of matrix components prior to their secretion. These modifications have broad impacts on the secretion and subsequent assembly of matrix components, as well as their function in the extracellular environment. In this Review, we highlight the role of the Golgi in the formation of an adaptable, healthy matrix, with a focus on proteoglycan and procollagen secretion as example cargoes. We then discuss the impact of Golgi dysfunction on connective tissue in the context of human disease and ageing.

Original language	English
Article number	jcs258879
Number of pages	20
Journal	Journal of Cell Science
Volume	135
Issue number	1
Early online date	13 Jan 2022
DOIs	https://doi.org/10.1242/jcs.258879
Publication status	E-pub ahead of print - 13 Jan 2022

Bibliographical note

Funding Information:
We are grateful to Professor Karl Kadler and Dr Yinhui Lu, Wellcome Centre for Cell-Matrix Research, University of Manchester, for providing the electron microscopy images of mouse tendon fibroblasts used in Fig. 1 and Movies 1 and 2. Fig. 2 was created with BioRender.com. We would like to acknowledge the Biotechnology and Biological Sciences Research Council (BBSRC; BB/T001984/1, awarded to D.S., M.L. and N.S.) and the University of Manchester and Singapore A*Star Institute (JH) for funding. Open access funding provided by University of Bristol. Deposited in PMC for immediate release.

Publisher Copyright:
© 2022. Published by The Company of Biologists Ltd

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Golgi complex
Collagen
Extracellular matrix
Glycosylation
Proteoglycans
Secretory pathway

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abstract = "The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation of the secretory pathway. The Golgi complex plays a vital role in directing matrix output by co-ordinating the post-translational modification and proteolytic processing of matrix components prior to their secretion. These modifications have broad impacts on the secretion and subsequent assembly of matrix components, as well as their function in the extracellular environment. In this Review, we highlight the role of the Golgi in the formation of an adaptable, healthy matrix, with a focus on proteoglycan and procollagen secretion as example cargoes. We then discuss the impact of Golgi dysfunction on connective tissue in the context of human disease and ageing.",

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AB - The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation of the secretory pathway. The Golgi complex plays a vital role in directing matrix output by co-ordinating the post-translational modification and proteolytic processing of matrix components prior to their secretion. These modifications have broad impacts on the secretion and subsequent assembly of matrix components, as well as their function in the extracellular environment. In this Review, we highlight the role of the Golgi in the formation of an adaptable, healthy matrix, with a focus on proteoglycan and procollagen secretion as example cargoes. We then discuss the impact of Golgi dysfunction on connective tissue in the context of human disease and ageing.

KW - Golgi complex

KW - Collagen

KW - Extracellular matrix

KW - Glycosylation

KW - Proteoglycans

KW - Secretory pathway

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DO - 10.1242/jcs.258879

M3 - Review article (Academic Journal)

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VL - 135

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ER -

Supply chain logistics - the role of the Golgi complex in extracellular matrix production and maintenance

Abstract

Bibliographical note

UN SDGs

Keywords

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