Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia

Nigel Melville Williams, A Preece, G Spurlock, N Norton, H J Williams, Stanley Zammit, Michael Conlon O'Donovan, Michael John Owen

Research output: Contribution to journalArticle (Academic Journal)peer-review

207 Citations (Scopus)

Abstract

Recently, it has been reported that genetic variants around the gene neuregulin 1 are associated with schizophrenia in an Icelandic sample. Of particular interest was the presence of a single-risk haplotype that was significantly over-represented in schizophrenic individuals compared to controls (15.4 : 7.5 P=6.7 x 10(-6)). We have attempted to replicate this result in our large collection of 573 schizophrenia cases and 618 controls. We found that the risk haplotype was more common in cases than controls (9.5 : 7.5 P=0.04), and especially in our subset of 141 cases with a family history of schizophrenia (11.6 P=0.019). Our results therefore replicate the Icelandic findings in an out-bred Northern European population, although they suggest that the risk conferred by the haplotype is small.
Original languageEnglish
Pages (from-to)485-487
Number of pages3
JournalMolecular Psychiatry
Volume8
Issue number5
DOIs
Publication statusPublished - 1 May 2003

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