Support for RGS4 as a susceptibility gene for schizophrenia

Nigel Melville Williams, Anna Charlotte Preece, Gillian Spurlock, Nadine Norton, Hywel John Williams, Robin G McCreadie, Paul Robert Buckland, Val Sharkey, Kodavali V. Chowdari, Stanley Zammit, Vishwajit Nimgaonkar, George Kirov, Michael John Owen, Michael Conlon O'Donovan

Research output: Contribution to journalArticle (Academic Journal)peer-review

113 Citations (Scopus)

Abstract

Background: The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator of G-protein signaling 4 as a schizophrenia candidate gene. Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples. Methods: We have examined a large case (n = 709) control (n = 710) sample for association between schizophrenia using four markers investigated in the earlier study, denoted single nucleotide polymorphisms 1, 4, 7, and 18. Results: We were able to replicate the associations with single nucleotide polymorphisms 4 and 18 that had previously been reported individually and have also identified significant association with haplotypes constructed from single nucleotide polymorphisms 1 and 4. Conclusions: Our data give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia.
Original languageEnglish
Pages (from-to)192-195
Number of pages4
JournalBiological Psychiatry
Volume55
Issue number2
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • Schizophrenia
  • candidate gene
  • association
  • reporter gene
  • promoter
  • haplotype

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