Suppression of Artefactual Time Courses in phMRI through Iterative Wavelet Cluster Analysis

McGonigle John, Majid Mirmehdi, Holmes Robin, Malizia Andrea L.

Research output: Contribution to journalArticle (Academic Journal)

Abstract

Wavelet-based cluster analysis (WCA) is a technique that can be used to separate fMRI and phMRI data into different clusters, where no model of the neural response is known a priori, based on the similarity of decomposed time courses at certain temporal scales. Here we extend this iteratively as an interactive step in a data-driven analysis. It works by removing voxels from further analysis by examining how they are clustered at temporal scales which may be different to that of any neural response under investigation. This is in contrast to existing techniques that suppress artefactual effects through excessive smoothing which may also suppress localised drug responses in phMRI. The method is demonstrated here on an auditory fMRI experiment. We conclude that it will be a useful step in the preprocessing and further analysis of phMRI data.
Translated title of the contributionSuppression of Artefactual Time Courses in phMRI through Iterative Wavelet Cluster Analysis
Original languageEnglish
Pages (from-to)199-203
JournalProceedings of Medical Image Understanding and Analysis 2008
Publication statusPublished - 2008

Bibliographical note

ISBN: 1901725359
Publisher: BMVA
Name and Venue of Conference: Proceedings of Medical Image Understanding and Analysis 2008
Other identifier: 2000886

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