supraHex: an R/Bioconductor package for tabular omics data analysis using a supra-hexagonal map

Hai Fang, Julian Gough

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Abstract

Biologists are increasingly confronted with the challenge of quickly understanding genome-wide biological data, which usually involve a large number of genomic coordinates (e.g. genes) but a much smaller number of samples. To meet the need for data of this shape, we present an open-source package called 'supraHex' for training, analysing and visualising omics data. This package devises a supra-hexagonal map to self-organise the input data, offers scalable functionalities for post-analysing the map, and more importantly, allows for overlaying additional data for multilayer omics data comparisons. Via applying to DNA replication timing data of mouse embryogenesis, we demonstrate that supraHex is capable of simultaneously carrying out gene clustering and sample correlation, providing intuitive visualisation at each step of the analysis. By overlaying CpG and expression data onto the trained replication-timing map, we also show that supraHex is able to intuitively capture an inherent relationship between late replication, low CpG density promoters and low expression levels. As part of the Bioconductor project, supraHex makes accessible to a wide community in a simple way, what would otherwise be a complex framework for the ultrafast understanding of any tabular omics data, both scientifically and artistically. This package can run on Windows, Mac and Linux, and is freely available together with many tutorials on featuring real examples at http://supfam.org/supraHex.
Original languageEnglish
Pages (from-to)285-9
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume443
Issue number1
DOIs
Publication statusPublished - 3 Jan 2014

Bibliographical note

Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

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