Survey Of Tissue Sub-Typing In Patients Diagnosed With Non-Small Cell Lung Cancer (NSCLC)

Rahul Bhatnagar, Sue Stevens, Lyndsae Wheen, Nicholas Withers

Research output: Contribution to conferenceConference Posterpeer-review


INTRODUCTION. With increasing potential for targeted treatments in NSCLC, it is especially important to accurately tissue type all patients at initial diagnosis. We have examined the pathological typing practice in the five Centres within our Cancer Network.
METHODS. Data was collected prospectively on all patients with a pathological diagnosis of NSCLC between 1st January 2010 and 31st March 2010. Information was collected on 1) type of specimen leading to a diagnosis; 2) use of immuno-staining and 3) certainty of final pathological sub-type.
RESULTS. A total of 115 specimens were reported on, of which 92 (80%) were histological. These comprised 43 bronchial biopsies, 35 CT-guided biopsies, 3 surgical biopsies and 11 of other types. Immuno-staining was undertaken in 58 (50.4%) cases, with proportions being similar for histological and cytological specimens (51% vs.48%). Table 1 shows the outcome for the certainty of the final pathological sub-type:
Histology (n=92) Cytology (n=23) TOTAL (n=115)
“Definite” 68 (74%) 9 (39%) 77 (67%)
“Probable” 20 (22%) 7 (30%) 27 (23%)
“Possible” 1 (1%) 3 (13%) 4 (3%)
No sub-type 3 (3%) 3 (13%) 6 (5%)
Missing Data 0 1 1
Data on the true sub-type was only provided for 88 cases, of whom 45 (51%) had adenocarcinoma, 42 (48%) squamous cell carcinoma and 1 adenosquamous.
Where immuno-staining was used, a definite sub-type was identified in 35 (60%) of cases compared with 42 (74%) in cases where no staining was undertaken.
A definitive tissue sub-type was identified from 32 (74%) of the bronchial biopsies, 24 (67%) of the CT-guided biopsies, 3 (100%) of the surgical biopsies and 8 (73%) of the biopsies from other sites.
CONCLUSIONS. Our results show that a definite or probable histological sub-type is identified in a sizeable majority of the cases of NSCLC diagnosed in our Cancer Network. Histological specimens provided a greater probability of determining a definitive sub-type than cytological specimens. The lower rate of definitive tissue sub-typing in cases where immuno-staining was used may reflect the fact that this technique tends to be used in cases where a sub-type is not certain on morphological grounds alone.
Original languageEnglish
Number of pages1
Publication statusPublished - 2011
EventAmerican Thoracic Society - Denver, United States
Duration: 15 May 201118 May 2011


ConferenceAmerican Thoracic Society
CountryUnited States

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