Survival Following Ruptured Abdominal Aortic Aneurysm Before and During the IMPROVE Trial: A Single-centre Series

Graeme K Ambler, Chris P Twine, J Shak, K E Rollins, K Varty, Patrick A Coughlin, P D Hayes, J R Boyle

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OBJECTIVES: The first large-scale randomised trial (Immediate Management of the Patient with Rupture: Open Versus Endovascular repair [IMPROVE]) for endovascular repair of ruptured abdominal aortic aneurysm (rEVAR) has recently finished recruiting patients. The aim of this study was to examine the impact on survival after rEVAR when the IMPROVE protocol was initiated in a high volume abdominal aortic aneurysm (AAA) centre previously performing rEVAR.

METHODS: One hundred and sixty-nine patients requiring emergency infrarenal AAA repair from January 2006 to April 2013 were included. Eighty-four patients were treated before (38 rEVAR, 46 open) and 85 (31 rEVAR, 54 open) were treated during the trial period. A retrospective analysis was performed.

RESULTS: Before the trial, there was a significant survival benefit for rEVAR over open repair (90-day mortality 13% vs. 30%, p = .04, difference remained significant up to 2 years postoperatively). This survival benefit was lost after starting randomisation (90-day mortality 35% vs. 33%, p = .93). There was an increase in overall 30-day mortality from 15% to 31% (p = .02), while there was no change for open repair (p = .438). There was a significant decrease in general anaesthetic use (p = .002) for patients treated during the trial. Randomised patients had shorter hospital and intensive treatment unit stays (p = .006 and p = .03 respectively).

CONCLUSIONS: The change in survival seen during the IMROVE trial highlights the need for randomised rather than cohort data to eliminate selection bias. These results from a single centre reinforce those recently reported in IMPROVE.

Original languageEnglish
Pages (from-to)388-393
Number of pages6
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number4
Early online date15 Feb 2014
Publication statusPublished - Apr 2014


  • Aged
  • Aged, 80 and over
  • Aortic Aneurysm, Abdominal/mortality
  • Aortic Rupture/mortality
  • Female
  • Hospital Mortality
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome
  • Vascular Surgical Procedures/methods

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