Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

Jithin D. Nair; Ellen Braksator; Busra P Yucel; Alexandra S Fletcher-Jones; Richard Seager; Jack R. Mellor; Zafar I. Bashir; Kevin A. Wilkinson; Jeremy M. Henley

doi:10.1016/j.isci.2021.103029

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

Jithin D. Nair, Ellen Braksator, Busra P Yucel, Alexandra S Fletcher-Jones, Richard Seager, Jack R. Mellor, Zafar I. Bashir, Kevin A. Wilkinson^*, Jeremy M. Henley^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Original language	English
Article number	103029
Number of pages	21
Journal	iScience
Volume	24
Issue number	9
DOIs	https://doi.org/10.1016/j.isci.2021.103029
Publication status	Published - 24 Sept 2021

Bibliographical note

Funding Information:
We are grateful to the Wolfson Bioimaging Facility (University of Bristol). We also thank the BBSRC ( BB/R00787X/1 ), MRC ( MR/L003791/1 ), Leverhulme Trust ( RPG-2019-191 ), and Wellcome Trust ( 105384/Z/14/A ) for financial support. The Graphical abstract in this article was made using BioRender.com software.

Funding Information:
We are grateful to the Wolfson Bioimaging Facility (University of Bristol). We also thank the BBSRC (BB/R00787X/1), MRC (MR/L003791/1), Leverhulme Trust (RPG-2019-191), and Wellcome Trust (105384/Z/14/A) for financial support. The Graphical abstract in this article was made using BioRender.com software. J.D.N. performed all the biochemistry and neuronal live surface staining experiments with help from A.F.-J. R.S. and B.P.Y. E.B. performed the electrophysiology guided by Z.I.B. DNA constructs were made by K.A.W. J.M.H. and K.A.W. supervised the study. J.D.N. K.A.W. and J.M.H. wrote, and all authors contributed to reading and editing the manuscript. The authors declare no competing interests.

Publisher Copyright:
© 2021 The Authors

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10.1016/j.isci.2021.103029

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@article{0209c059e52c45f5a643a15dd1125edf,

title = "Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD",

author = "Nair, {Jithin D.} and Ellen Braksator and Yucel, {Busra P} and Fletcher-Jones, {Alexandra S} and Richard Seager and Mellor, {Jack R.} and Bashir, {Zafar I.} and Wilkinson, {Kevin A.} and Henley, {Jeremy M.}",

note = "Funding Information: We are grateful to the Wolfson Bioimaging Facility (University of Bristol). We also thank the BBSRC ( BB/R00787X/1 ), MRC ( MR/L003791/1 ), Leverhulme Trust ( RPG-2019-191 ), and Wellcome Trust ( 105384/Z/14/A ) for financial support. The Graphical abstract in this article was made using BioRender.com software. Funding Information: We are grateful to the Wolfson Bioimaging Facility (University of Bristol). We also thank the BBSRC (BB/R00787X/1), MRC (MR/L003791/1), Leverhulme Trust (RPG-2019-191), and Wellcome Trust (105384/Z/14/A) for financial support. The Graphical abstract in this article was made using BioRender.com software. J.D.N. performed all the biochemistry and neuronal live surface staining experiments with help from A.F.-J. R.S. and B.P.Y. E.B. performed the electrophysiology guided by Z.I.B. DNA constructs were made by K.A.W. J.M.H. and K.A.W. supervised the study. J.D.N. K.A.W. and J.M.H. wrote, and all authors contributed to reading and editing the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2021 The Authors",

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doi = "10.1016/j.isci.2021.103029",

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T1 - Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

AU - Nair, Jithin D.

AU - Braksator, Ellen

AU - Yucel, Busra P

AU - Fletcher-Jones, Alexandra S

AU - Seager, Richard

AU - Mellor, Jack R.

AU - Bashir, Zafar I.

AU - Wilkinson, Kevin A.

AU - Henley, Jeremy M.

N1 - Funding Information: We are grateful to the Wolfson Bioimaging Facility (University of Bristol). We also thank the BBSRC ( BB/R00787X/1 ), MRC ( MR/L003791/1 ), Leverhulme Trust ( RPG-2019-191 ), and Wellcome Trust ( 105384/Z/14/A ) for financial support. The Graphical abstract in this article was made using BioRender.com software. Funding Information: We are grateful to the Wolfson Bioimaging Facility (University of Bristol). We also thank the BBSRC (BB/R00787X/1), MRC (MR/L003791/1), Leverhulme Trust (RPG-2019-191), and Wellcome Trust (105384/Z/14/A) for financial support. The Graphical abstract in this article was made using BioRender.com software. J.D.N. performed all the biochemistry and neuronal live surface staining experiments with help from A.F.-J. R.S. and B.P.Y. E.B. performed the electrophysiology guided by Z.I.B. DNA constructs were made by K.A.W. J.M.H. and K.A.W. supervised the study. J.D.N. K.A.W. and J.M.H. wrote, and all authors contributed to reading and editing the manuscript. The authors declare no competing interests. Publisher Copyright: © 2021 The Authors

PY - 2021/9/24

Y1 - 2021/9/24

U2 - 10.1016/j.isci.2021.103029

DO - 10.1016/j.isci.2021.103029

M3 - Article (Academic Journal)

C2 - 34553130

SN - 2589-0042

VL - 24

JO - iScience

JF - iScience

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ER -